Document Detail

Timed IVM followed by ICSI in a patient with immature ovarian oocytes.
MedLine Citation:
PMID:  16820119     Owner:  NLM     Status:  MEDLINE    
A complete failure of meiotic maturation occasionally occurs following human chorionic gonadotrophin administration during IVF-intracytoplasmic sperm injection (ICSI) cycles. ICSI on day 1 is commonly used to allow maturation in culture. However, if the oocytes become mature in the evening soon after their recovery but ICSI is delayed until the next day, then subsequent ageing of matured oocytes may be unfavourable for fertilization and development. To avoid the deterioration associated with oocyte ageing, the timing of polar body extrusion was checked every 3 h and rescue in-vitro maturation (IVM)-ICSI was performed shortly after the polar body extrusion was confirmed. This report describes a successful pregnancy and birth of a healthy baby in a patient who had no mature oocytes at the time of oocyte retrieval, and illustrates the value of extra monitoring for IVM and ICSI in cases where only immature oocytes are available.
Junko Otsuki; Yoshie Momma; Keiko Takahashi; Sachie Miyakura; Yasushi Nagai
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Publication Detail:
Type:  Case Reports; In Vitro; Journal Article    
Journal Detail:
Title:  Reproductive biomedicine online     Volume:  13     ISSN:  1472-6483     ISO Abbreviation:  Reprod. Biomed. Online     Publication Date:  2006 Jul 
Date Detail:
Created Date:  2006-07-05     Completed Date:  2006-09-08     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  101122473     Medline TA:  Reprod Biomed Online     Country:  England    
Other Details:
Languages:  eng     Pagination:  101-3     Citation Subset:  IM    
Nagai Clinic, 607-1 Misato Saitama 341-0004, Japan.
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MeSH Terms
Cell Aging
Cell Differentiation
Infant, Newborn
Oocytes / cytology*,  growth & development*
Reproductive Techniques, Assisted
Sperm Injections, Intracytoplasmic*
Time Factors

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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