Document Detail

Time-trends in necropsy prevalence and birth prevalence of lung hypoplasia.
MedLine Citation:
PMID:  2587409     Owner:  NLM     Status:  MEDLINE    
Congenital lung hypoplasia (LH) has been identified with increasing frequency in perinatal and neonatal necropsy reviews. The available prevalence figures have been derived using various diagnostic criteria in different populations and at various times. We therefore reviewed our experience in 15 years of consecutive early neonatal necropsies using one constant set of diagnostic criteria for LH and looked for a time-trend. We determined the necropsy prevalence (no. of cases of LH/no. of necropsies) and the birth prevalence (no. of cases of LH documented at necropsy per 1000 livebirths for inborn patients, and per 1000 referrals for outborn patients) between 1971 and 1985. We then divided this 15-year period into five consecutive 3-year periods to determine if a time-trend was discernible. Whereas early neonatal mortality for neonatal intensive care unit (NICU) admissions progressively decreased from 11.4% to 4.0% between the first and the last 3-year periods, the number of cases of LH per 3-year period did not vary appreciably. As a result, the prevalence of LH at necropsy showed a slight upward trend with time. The overall prevalence was 18%; it was 13% during the first and 23% during the last 3-year period. We found no time-trend in birth or referral prevalence for this lesion, which averaged 1.1 per 1000 livebirths and 9.8 per 1000 referrals. We conclude that lung hypoplasia appears to be emerging as an increasingly prevalent necropsy finding as a result of a shift in proportionate mortality, with the number of patients dying of other causes (denominator) decreasing, and the number of patients dying with lung hypoplasia remaining constant.
A C Moessinger; A Santiago; N S Paneth; H R Rey; W A Blanc; J M Driscoll
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Paediatric and perinatal epidemiology     Volume:  3     ISSN:  0269-5022     ISO Abbreviation:  Paediatr Perinat Epidemiol     Publication Date:  1989 Oct 
Date Detail:
Created Date:  1989-12-28     Completed Date:  1989-12-28     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  8709766     Medline TA:  Paediatr Perinat Epidemiol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  421-31     Citation Subset:  IM    
Department of Pediatrics, College of Physicians and Surgeons of Columbia University, New York, NY.
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MeSH Terms
Cause of Death*
Cross-Sectional Studies
Infant, Newborn
Lung / abnormalities*,  pathology
New York / epidemiology
Respiratory Distress Syndrome, Newborn / mortality*,  pathology
Retrospective Studies
Grant Support

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