| Time trends in the HERS secondary prevention trial: much ado about nothing? | |
MedLine Citation:
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PMID: 12405240 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The Heart and Estrogen/progestin Replacement Study was the first randomized, double-blind, placebo-controlled study evaluating whether hormone replacement therapy (HRT) reduces the incidence of nonfatal myocardial infarction (MI) and coronary heart disease (CHD) death. The main conclusion was that HRT provided no benefit for secondary prevention. This paper examines the statistical evidence for a subsidiary analysis suggesting that the effects of HRT varied over time; that the HRT group had more cardiac events in year 1, but fewer by the last years of the study. An accurate reading of the HERS results indicates an increased incidence of MI and CHD death in the HRT group in year 1, but no evidence that the HRT group had fewer CHD events by the end of the study. |
Authors:
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Paula S Derry |
Publication Detail:
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Type: Clinical Trial; Journal Article; Randomized Controlled Trial |
Journal Detail:
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Title: Journal of the American Medical Women's Association (1972) Volume: 57 ISSN: 0098-8421 ISO Abbreviation: J Am Med Womens Assoc Publication Date: 2002 |
Date Detail:
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Created Date: 2002-10-30 Completed Date: 2002-11-22 Revised Date: 2009-11-19 |
Medline Journal Info:
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Nlm Unique ID: 7503064 Medline TA: J Am Med Womens Assoc Country: United States |
Other Details:
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Languages: eng Pagination: 215-6 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Death, Sudden, Cardiac / epidemiology*, prevention & control Drug Combinations Estrogen Replacement Therapy / adverse effects* Estrogens, Conjugated (USP) / adverse effects* Female Humans Medroxyprogesterone Acetate / adverse effects* Myocardial Infarction / chemically induced, epidemiology*, prevention & control Progesterone Congeners / adverse effects* Randomized Controlled Trials as Topic Treatment Outcome |
| Chemical | |
Reg. No./Substance:
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0/Drug Combinations; 0/Estrogens, Conjugated (USP); 0/Prempro; 0/Progesterone Congeners; 71-58-9/Medroxyprogesterone Acetate |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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