Document Detail

Time trends in the HERS secondary prevention trial: much ado about nothing?
MedLine Citation:
PMID:  12405240     Owner:  NLM     Status:  MEDLINE    
The Heart and Estrogen/progestin Replacement Study was the first randomized, double-blind, placebo-controlled study evaluating whether hormone replacement therapy (HRT) reduces the incidence of nonfatal myocardial infarction (MI) and coronary heart disease (CHD) death. The main conclusion was that HRT provided no benefit for secondary prevention. This paper examines the statistical evidence for a subsidiary analysis suggesting that the effects of HRT varied over time; that the HRT group had more cardiac events in year 1, but fewer by the last years of the study. An accurate reading of the HERS results indicates an increased incidence of MI and CHD death in the HRT group in year 1, but no evidence that the HRT group had fewer CHD events by the end of the study.
Paula S Derry
Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Journal of the American Medical Women's Association (1972)     Volume:  57     ISSN:  0098-8421     ISO Abbreviation:  J Am Med Womens Assoc     Publication Date:  2002  
Date Detail:
Created Date:  2002-10-30     Completed Date:  2002-11-22     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  7503064     Medline TA:  J Am Med Womens Assoc     Country:  United States    
Other Details:
Languages:  eng     Pagination:  215-6     Citation Subset:  IM    
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MeSH Terms
Death, Sudden, Cardiac / epidemiology*,  prevention & control
Drug Combinations
Estrogen Replacement Therapy / adverse effects*
Estrogens, Conjugated (USP) / adverse effects*
Medroxyprogesterone Acetate / adverse effects*
Myocardial Infarction / chemically induced,  epidemiology*,  prevention & control
Progesterone Congeners / adverse effects*
Randomized Controlled Trials as Topic
Treatment Outcome
Reg. No./Substance:
0/Drug Combinations; 0/Estrogens, Conjugated (USP); 0/Prempro; 0/Progesterone Congeners; 71-58-9/Medroxyprogesterone Acetate

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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