Document Detail

Time trends (1978-86) of anencephaly and spina bifida in four hospitals affiliated with the International Clearinghouse: a warning.
MedLine Citation:
PMID:  2670819     Owner:  NLM     Status:  MEDLINE    
The prevalence and time trends of spina bifida and anencephaly in the central area of Israel have been studied using data derived from four hospitals affiliated with the International Clearinghouse for Birth Defects Monitoring Systems. Spina bifida rates show a continuous increase from 1978 (1.1/10,000) to 1986 (7.4/10,000) with a peak in 1984 (7-fold increase compared with 1978). The logistic regression analysis of proportion of cases revealed a significant linear trend over time (P less than 0.005). Anencephaly rates increased from 1978 to 1981 but later decreased continuously until 1986 when the prevalence returned to the initial level of 1978. This time trend of spina bifida may represent a real alarm; the implications of this observation are discussed.
P Merlob; B M Mogilner; B Muhlbauer; I Aitkin; F Dulitzky
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Israel journal of medical sciences     Volume:  25     ISSN:  0021-2180     ISO Abbreviation:  Isr. J. Med. Sci.     Publication Date:  1989 Aug 
Date Detail:
Created Date:  1989-09-27     Completed Date:  1989-09-27     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0013105     Medline TA:  Isr J Med Sci     Country:  ISRAEL    
Other Details:
Languages:  eng     Pagination:  441-4     Citation Subset:  IM    
Department of Neonatology, Beilinson Medical Center, Petah Tikva, Israel.
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MeSH Terms
Anencephaly / epidemiology*,  prevention & control
Infant, Newborn
Mass Screening
Spina Bifida Occulta / epidemiology*,  prevention & control
Time Factors

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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