Document Detail

Time to twist: marker of systolic dysfunction in Africans with hypertension.
MedLine Citation:
PMID:  22918406     Owner:  NLM     Status:  Publisher    
AIMS: Speckle-tracking echocardiography (STE) has emerged as a quantitative technique to assess left ventricular (LV) function via twist mechanics. Hypertension-associated changes in LV twist have not been previously evaluated in African patients with LV systolic dysfunction. This study evaluates LV twist dynamics in hypertensive patients with a low ejection fraction (EF). METHODS AND RESULTS: Forty-one hypertensive patients with EF <45% and normal coronary angiography (HTLEF group) were compared with 41 control subjects using STE. Peak apical rotation (AR) and isochronous basal rotation (BR) were measured, as was net twist (maximal value of simultaneous AR-BR). Rigid body rotation (RBR) was defined as AR and BR occurring in the same direction. Of 41 HTLEF patients, 28 (68%) had normal twist pattern, whereas 13 (32%) exhibited RBR; 11 of those 13 exhibited clockwise rotation. AR (1.89° ± 0.99 vs. 7.15° ± 2.26; P < 0.0001), BR (1.44° ± 0.78 vs. -3.75° ± 1.61; P < 0.0001), and net twist (3.3° ± 1.17 vs. 10.9° ± 2.7; P < 0.0001) were lower in HTLEF patients. The subgroup with clockwise RBR showed greater LV dysfunction (EF: 27.9 ± 5.8 vs. 35 ± 7.5%; P = 0.005) and more spherical LV geometry in both diastole and systole (P = 0.0009 and P = 0.0002, respectively) compared with those who had a normal pattern of twist. In the HTLEF subgroup with normal twist pattern, AR (r = 0.57; P = 0.002) and net twist (r = 0.57; P = 0.002) correlated with EF. CONCLUSIONS: LV twist in patients with hypertension and EF <45% is diminished. Apical rotation and net twist are good correlates for EF in hypertensive patients with EF <45%.
Nirvarthi Maharaj; Bijoy K Khandheria; Ferande Peters; Elena Libhaber; Mohammed R Essop
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-8-22
Journal Detail:
Title:  European heart journal cardiovascular Imaging     Volume:  -     ISSN:  2047-2412     ISO Abbreviation:  Eur Heart J Cardiovasc Imaging     Publication Date:  2012 Aug 
Date Detail:
Created Date:  2012-8-24     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101573788     Medline TA:  Eur Heart J Cardiovasc Imaging     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Division of Cardiology, Chris Hani Baragwanath Hospital and University of the Witwatersrand, Johannesburg, South Africa.
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