Document Detail


Time-to-time correlation of high-risk atherosclerotic lesions identified with [(18)F]-FDG-PET/CT.
MedLine Citation:
PMID:  19205839     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: It has been shown that [(18)F]-fluorodeoxyglucose positron emission tomography/computed tomography (FDG-PET/CT) can identify macrophage-rich high-risk atherosclerotic plaques in animal models as well as in patients with atherosclerotic plaques in the carotid arteries. The development of inflamed macrophage-rich plaques over time is not well known. This study was performed to determine the variability of such FDG-accumulating plaques between consecutive PET/CT examinations. METHODS: Twenty-eight patients who underwent two whole-body FDG-PET/CT examinations within 7 months for malignant diseases were re-evaluated for atherosclerotic lesions in major arterial segments. The plaques were identified as active, inactive, or mixed depending on their appearance on PET and CT. Every identified plaque was compared with that of the other examination to evaluate the time-to-time correlation. RESULTS: The time-to-time correlation was close to 100% for calcified inactive plaques and about 50% for FDG-accumulating active plaques, with a high consistency between all examined arterial segments in this material. CONCLUSIONS: A large proportion of FDG-accumulating plaques can be identified on consecutive FDG-PET/CT examinations within 7 months.
Authors:
Johan Wassélius; Stig Larsson; Hans Jacobsson
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2009-02-11
Journal Detail:
Title:  Annals of nuclear medicine     Volume:  23     ISSN:  0914-7187     ISO Abbreviation:  Ann Nucl Med     Publication Date:  2009 Jan 
Date Detail:
Created Date:  2009-02-11     Completed Date:  2009-04-16     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8913398     Medline TA:  Ann Nucl Med     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  59-64     Citation Subset:  IM    
Affiliation:
Department of Radiology, Karolinska University Hospital, SE-171 76 Stockholm, Sweden. johan.wasselius@karolinska.se
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MeSH Terms
Descriptor/Qualifier:
Atherosclerosis / diagnosis*
Calcinosis / diagnosis*
Female
Fluorodeoxyglucose F18 / diagnostic use*
Humans
Male
Positron-Emission Tomography / methods*
Radiopharmaceuticals / diagnostic use
Reproducibility of Results
Sensitivity and Specificity
Statistics as Topic
Subtraction Technique
Time Factors
Tomography, X-Ray Computed / methods*
Chemical
Reg. No./Substance:
0/Radiopharmaceuticals; 63503-12-8/Fluorodeoxyglucose F18

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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