Document Detail

Time to pregnancy and semen parameters: a cross-sectional study among fertile couples from four European cities.
MedLine Citation:
PMID:  11821304     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: In fertile populations, little is known about the association between semen parameters and time to pregnancy (TTP). METHODS: Pregnant women from Copenhagen, Edinburgh, Paris and Turku who conceived without medical intervention were asked for their TTP (942 couples), and their partners provided a semen sample. The proportion of morphologically normal sperm and the multiple anomalies index (MAI, ratio of the total number of anomalies to the number of abnormal sperm) were centrally estimated. We estimated rate ratios for the occurrence of a pregnancy by a discrete survival model, adjusted for sexual activity and female factors affecting fecundity. RESULTS: Increasing sperm concentration influenced TTP up to 55 x 10(6)/ml. The proportion of morphologically normal sperm influenced TTP up to 39% according to David's criteria, and this association held among the subjects with a sperm concentration >55 x 10(6)/ml. For strict criteria, the threshold value was 19% normal sperm. An increase of 0.5 in MAI was associated with an adjusted rate ratio for the occurrence of a pregnancy of 0.68 (95% confidence interval: 0.54-0.85). CONCLUSIONS: These results highlight the importance of sperm morphology parameters and indicate that the effect of proportion of normal sperm on TTP may be independent of sperm concentration.
R Slama; F Eustache; B Ducot; T K Jensen; N Jørgensen; A Horte; S Irvine; J Suominen; A G Andersen; J Auger; M Vierula; J Toppari; A N Andersen; N Keiding; N E Skakkebaek; A Spira; P Jouannet
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Human reproduction (Oxford, England)     Volume:  17     ISSN:  0268-1161     ISO Abbreviation:  Hum. Reprod.     Publication Date:  2002 Feb 
Date Detail:
Created Date:  2002-01-31     Completed Date:  2002-04-23     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8701199     Medline TA:  Hum Reprod     Country:  England    
Other Details:
Languages:  eng     Pagination:  503-15     Citation Subset:  IM    
INSERM U292, Research in Public Health, 82 rue du Général Leclerc, 94276 Le Kremlin-Bicêtre cedex, France.
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MeSH Terms
Cross-Sectional Studies
Semen / physiology*
Sperm Count
Spermatozoa / cytology
Time Factors

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