| Time to pregnancy among the wives of men exposed to organic solvents. | |
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MedLine Citation:
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PMID: 9536159 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVES: To assess whether paternal exposure to organic solvents is associated with decreased fertility. METHODS: A retrospective time to pregnancy study was conducted among men biologically monitored for organic solvents. The workers were classified into exposure categories on the basis of work description and the use of solvents as reported in the questionnaires, and on biological exposure measurements. The relative fecundability density ratios (FDR--an analogue of incidence density ratio of clinically recognised pregnancies) were calculated with discrete proportional hazards regression. RESULTS: After three mailings 316 (72.1%) wives of the monitored men participated. The final study population consisted of 282 couples who did not use contraception at the beginning of pregnancy. The FDRs, adjusted for potential confounders, were 0.80 (95% confidence interval (95% CI) 0.57 to 1.11) and 0.74 (95% CI 0.51 to 1.06) for high or frequent and low or intermediate exposure, respectively. High or frequent and low or intermediate exposure were related to decreased fecundability among primigravida (FDRs 0.36; 95% CI 0.19 to 0.66 and 0.53; 95% CI 0.27 to 1.04) but not among couples with at least one previous pregnancy (FDRs 0.96; 95% CI 0.62 to 1.49 and 0.77; 95% CI 0.47 to 1.24). CONCLUSIONS: The findings of the study provide limited support for the hypothesis that paternal exposure to organic solvents might be associated with decreased fertility. Further studies with careful design are warranted. |
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Authors:
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M Sallmén; M L Lindbohm; A Anttila; P Kyyrönen; H Taskinen; E Nykyri; K Hemminki |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Occupational and environmental medicine Volume: 55 ISSN: 1351-0711 ISO Abbreviation: Occup Environ Med Publication Date: 1998 Jan |
Date Detail:
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Created Date: 1998-04-15 Completed Date: 1998-04-15 Revised Date: 2009-11-18 |
Medline Journal Info:
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Nlm Unique ID: 9422759 Medline TA: Occup Environ Med Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 24-30 Citation Subset: IM |
Affiliation:
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Finnish Institute of Occupational Health, Department of Epidemiology and Biostatistics, Helsinki, Finland. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Confounding Factors (Epidemiology) Dose-Response Relationship, Drug Female Fertility / drug effects* Humans Male Occupational Exposure / adverse effects* Paternal Exposure / adverse effects* Pregnancy Proportional Hazards Models Retrospective Studies Solvents / adverse effects* Time Factors |
| Chemical | |
Reg. No./Substance:
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0/Solvents |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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