| Time-to-pregnancy among male greenhouse workers. | |
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MedLine Citation:
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PMID: 17855503 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVES: Fertility problems are an increasing public health issue in industrialised countries. Exposure to exogenous agents with endocrine disrupting properties, such as some pesticides, are potential risk factors for subfertility. The aim of this study was to determine whether time-to-pregnancy (TTP) is prolonged in male greenhouse workers exposed to pesticides in comparison with a non-exposed reference group. METHODS: Data were collected through self-administrated questionnaires with detailed questions on TTP, as well as on lifestyle (for example, smoking habits, coffee and alcohol consumption), work tasks, and occupational exposures of the men and their partners in the six months before conception of the most recent pregnancy. TTP was compared between male greenhouse workers (n = 694) and a non-exposed reference group (n = 613) by means of discrete proportional hazards regression analysis. RESULTS: The crude analyses did not show a decreased overall fecundability among greenhouse workers compared to the non-exposed reference group. However, when fecundability was assessed for primigravidous couples, duogravidous couples, and multigravidous couples separately, greenhouse workers were found to be less fecund when trying to conceive their first pregnancy (FR = 0.65; 95% CI 0.46 to 0.92), which is also the most valid analysis in which pregnancy planning issues were avoided. Among couples who already experienced one or more pregnancies, no association was seen between pesticide exposure and TTP after adjustment for confounders. CONCLUSION: A prolonged time-to-pregnancy was observed in male greenhouse workers exposed to pesticides before conception of their first pregnancy. |
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Authors:
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R Bretveld; S Kik; M Hooiveld; I van Rooij; G Zielhuis; N Roeleveld |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2007-09-12 |
Journal Detail:
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Title: Occupational and environmental medicine Volume: 65 ISSN: 1470-7926 ISO Abbreviation: Occup Environ Med Publication Date: 2008 Mar |
Date Detail:
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Created Date: 2008-02-19 Completed Date: 2008-03-11 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9422759 Medline TA: Occup Environ Med Country: England |
Other Details:
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Languages: eng Pagination: 185-90 Citation Subset: IM |
Affiliation:
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Department of Epidemiology and Biostatistics (HP 133), Radboud University Nijmegen Medical Centre, PO Box 9101, 6500 HB Nijmegen, The Netherlands. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Case-Control Studies Confounding Factors (Epidemiology) Female Fertilization Gardening* Humans Infertility, Male / chemically induced* Male Multivariate Analysis Occupational Exposure* Odds Ratio Parity Paternal Exposure* Pesticides / toxicity* Pregnancy Time Factors |
| Chemical | |
Reg. No./Substance:
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0/Pesticides |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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