Document Detail

Time to extubation in infants undergoing pyloromyotomy -- isoflurane inhalation vs remifentanil infusion.
MedLine Citation:
PMID:  19583078     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Infantile hypertrophic pyloric stenosis (IHPS) associated with metabolic alkalosis, could induce late anesthesia recovery, especially when opioids are used. The aim of this study was to compare the time of extubation and the quality of perioperative analgesia in infants scheduled for pyloromyotomy, receiving either isoflurane inhalation or remifentanil infusion.
METHODS: Thirty full-term infants scheduled for pyloromyotomy were prospectively studied. A standardized anesthetic induction was performed. For maintenance of anesthesia, infants were randomly allocated to receive either isoflurane 0.75% of inspired concentration (GI n = 15), or remifentanil as a continuous infusion of 0.4 microg x kg(-1) x mn(-1) (GR n = 15). At the beginning of skin closure, the anesthetic was discontinued and 15 mg x kg(-1) of paracetamol administered. Non parametric tests were used in statistical analysis.
RESULTS: The time to extubation was similar in both groups. The intraoperative heart rate was significantly lower in the GR group.
CONCLUSION: Remifentanil provided better intraoperative analgesia than isoflurane in infants undergoing pyloromyotomy without increasing time to extubation.
Sonia Ben Khalifa; Sami Blidi; Mehdi Trifa; Alia Skhiri; Mehdi Drira; Tarek Regaya; Amjed Fekih Hassen
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Publication Detail:
Type:  Comparative Study; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Middle East journal of anaesthesiology     Volume:  20     ISSN:  0544-0440     ISO Abbreviation:  Middle East J Anaesthesiol     Publication Date:  2009 Jun 
Date Detail:
Created Date:  2009-07-08     Completed Date:  2009-08-04     Revised Date:  2014-10-10    
Medline Journal Info:
Nlm Unique ID:  8604187     Medline TA:  Middle East J Anaesthesiol     Country:  Lebanon    
Other Details:
Languages:  eng     Pagination:  277-80     Citation Subset:  IM    
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MeSH Terms
Acetaminophen / therapeutic use
Analgesics, Non-Narcotic / therapeutic use
Anesthetics, Inhalation / therapeutic use
Anesthetics, Intravenous / therapeutic use*
Heart Rate / drug effects
Infant, Newborn
Intubation, Intratracheal
Isoflurane / therapeutic use*
Perioperative Care
Piperidines / therapeutic use*
Prospective Studies
Pyloric Stenosis, Hypertrophic / surgery
Single-Blind Method
Time Factors
Reg. No./Substance:
0/Analgesics, Non-Narcotic; 0/Anesthetics, Inhalation; 0/Anesthetics, Intravenous; 0/Piperidines; 362O9ITL9D/Acetaminophen; CYS9AKD70P/Isoflurane; P10582JYYK/remifentanil

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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