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Time to disappearance of thyroglobulin antibodies and influencing factors in patients with papillary thyroid carcinoma.
MedLine Citation:
PMID:  22776660     Owner:  NLM     Status:  In-Data-Review    
Objective To investigate the time to disappearance of thyroglobulin antibodies (TgAb) and its influencing factors in papillary thyroid carcinoma (PTC) patients with positive TgAb after radioiodine ((131)I) ablation. Methods We retrospectively analyzed the clinical data of 64 PTC patients who had undergone a total thyroidectomy and subsequent (131)I therapy. Patients were divided into two groups according to the presence of concurrent Hashimoto thyroiditis (HD). TgAb1 (TgAb levels determined before (131)I therapy) were above the normal thresholds in all patients. The method of survival analysis (including Life tables and Cox Regression analysis) was used to assess the time to disappearance of TgAb and its influencing factors. Results The median time to disappearance of positive TgAb (9.0 months vs. 10.4 months, P=0.923) showed no significant difference between these two groups. Cox Regression analysis showed that, among the potential influencing factors including TgAb [partial regression coefficient (B)=-0.004, P=0.001], age(B=-0.018, P=0.362), sex (B=0.644, P=0.320) and HD (B=0.341, P=0.372), only TgAb1 was correlated with the TgAb negative conversion time. Conclusions TgAb1 has remarked influence on the time to disappearance of positive TgAb in PTC patients. Patients with a higher TgAb need longer time to achieve negative conversion.
Li Tian-Jun; Lin Yan-Song; Liang Jun; Li Fang
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae     Volume:  34     ISSN:  1000-503X     ISO Abbreviation:  Zhongguo Yi Xue Ke Xue Yuan Xue Bao     Publication Date:  2012 Jun 
Date Detail:
Created Date:  2012-07-10     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8006230     Medline TA:  Zhongguo Yi Xue Ke Xue Yuan Xue Bao     Country:  China    
Other Details:
Languages:  eng     Pagination:  258-61     Citation Subset:  IM    
Department of Oncology, the Affiliated Hospital of Qingdao University Medical College, Qingdao 266003, China.
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