Document Detail

Time to stop blaming gastroesophageal reflux.
MedLine Citation:
PMID:  21685210     Owner:  NLM     Status:  MEDLINE    
OBJECTIVES. Cough, pain, and desaturation episodes in infants are often ascribed to gastroesophageal reflux, and many are empirically treated with acid suppression medications. The authors hypothesize that most of these symptoms are not related to gastroesophageal reflux. METHODS. Retrospective review of 186 combined pH-multichannel intraluminal impedance studies performed in infants at Cincinnati Children's Hospital. RESULTS. Of 4159 symptoms reported 1504 (36%) were associated with reflux events (27% nonacid and 9% acid). When total number of symptoms and reflux events were taken into consideration, nonacid reflux events were as likely to be associated with a symptom as acid reflux events (P = .66). CONCLUSION. The extra-esophageal symptoms commonly attributed to gastroesophageal reflux in infants are most often not associated with a reflux event. Even though causality cannot be definitively proven, in the minority in whom a symptom association is observed, nonacid events are as likely as acid events to cause symptoms.
Jose M Garza; Cade M Nylund; Ajay Kaul
Publication Detail:
Type:  Journal Article     Date:  2011-06-17
Journal Detail:
Title:  Clinical pediatrics     Volume:  50     ISSN:  1938-2707     ISO Abbreviation:  Clin Pediatr (Phila)     Publication Date:  2011 Dec 
Date Detail:
Created Date:  2011-11-28     Completed Date:  2012-08-30     Revised Date:  2013-08-23    
Medline Journal Info:
Nlm Unique ID:  0372606     Medline TA:  Clin Pediatr (Phila)     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1110-5     Citation Subset:  AIM; IM    
Cincinnati Children's Hospital Medical Center, OH, USA.
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MeSH Terms
2-Pyridinylmethylsulfinylbenzimidazoles / therapeutic use
Cough / etiology*
Diagnosis, Differential
Electric Impedance / diagnostic use
Enzyme Inhibitors / therapeutic use
Esophageal pH Monitoring
Gastroesophageal Reflux / complications,  diagnosis*,  drug therapy
Histamine H2 Antagonists / therapeutic use
Laryngopharyngeal Reflux / etiology
Logistic Models
Pain / etiology*
Ranitidine / therapeutic use
Retrospective Studies
Grant Support
Reg. No./Substance:
0/2-Pyridinylmethylsulfinylbenzimidazoles; 0/Enzyme Inhibitors; 0/Histamine H2 Antagonists; 103577-45-3/lansoprazole; 66357-35-5/Ranitidine

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