Document Detail

Time-related changes in salivary levels of the osteotropic factors sRANKL and OPG through orthodontic tooth movement.
MedLine Citation:
PMID:  23273364     Owner:  NLM     Status:  MEDLINE    
INTRODUCTION: In this study, we aimed to determine whether the variations in salivary concentrations of soluble receptor activator of nuclear factor kappa B ligand (sRANKL) and osteoprotegerin (OPG), and their ratios, might be linked with the different phases of orthodontic tooth movement.
METHODS: Twenty healthy subjects who required fixed appliance therapy not involving tooth extractions or surgical procedures were selected. Unstimulated whole saliva samples were collected from each patient before fitting the orthodontic appliances, and at 24 to 48 hours, 2 weeks, 5 weeks, and 8 weeks after the activation. Salivary sRANKL and OPG concentrations were determined by enzyme-linked immunosorbent assays. The data were analyzed by using nonparametric statistics.
RESULTS: Overall, median values of sRANKL showed significant increases, median OPG salivary values showed a significant downward trend, and the sRANKL/OPG ratio tended to increase significantly over time after the activation visit. However, clear fluctuations in the immunoenzymatic findings were noted at the different sampling times, indicating nonlinear trends in the levels of the biomarkers through time. Post-hoc pairwise comparisons showed significant differences between (1) all sRANKL values relative to those of the 8-week sampling time; (2) baseline/8-week OPG salivary levels; and (3) baseline, 24 to 48 hours, and 2-week sRANKL/OPG ratios compared with those of the 8-week test.
CONCLUSIONS: The findings indicate that variations in salivary concentrations of sRANKL and OPG and their ratios might be linked to the different phases of orthodontic tooth movement. Hence, these analytes might serve in a panel of salivary functional biomarkers that could assist in the screening of orthodontic treatment in clinical practice.
Gloria Amparo Flórez-Moreno; Diana María Isaza-Guzmán; Sergio Iván Tobón-Arroyave
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  American journal of orthodontics and dentofacial orthopedics : official publication of the American Association of Orthodontists, its constituent societies, and the American Board of Orthodontics     Volume:  143     ISSN:  1097-6752     ISO Abbreviation:  Am J Orthod Dentofacial Orthop     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2012-12-31     Completed Date:  2013-02-19     Revised Date:  2013-05-15    
Medline Journal Info:
Nlm Unique ID:  8610224     Medline TA:  Am J Orthod Dentofacial Orthop     Country:  United States    
Other Details:
Languages:  eng     Pagination:  92-100     Citation Subset:  D; IM    
Copyright Information:
Copyright © 2013 American Association of Orthodontists. Published by Mosby, Inc. All rights reserved.
Associate professor, Clinical Orthodontics, Grupo de Investigación en Patología Oral, Periodoncia y Cirugía Alvéolo-Dentaria (POPCAD), Faculty of Dentistry, University of Antioquia, Medellín, Colombia.
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MeSH Terms
Alveolar Process / metabolism*
Biological Markers / metabolism
Middle Aged
Orthodontic Appliances
Osteoprotegerin / biosynthesis*
Prospective Studies
RANK Ligand / biosynthesis*
Saliva / chemistry*
Time Factors
Tooth Movement* / instrumentation
Young Adult
Reg. No./Substance:
0/Biological Markers; 0/Osteoprotegerin; 0/RANK Ligand
Comment In:
Am J Orthod Dentofacial Orthop. 2013 Apr;143(4):447-8   [PMID:  23561401 ]
Am J Orthod Dentofacial Orthop. 2013 Apr;143(4):446-7   [PMID:  23561400 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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