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Time-related analysis of ductus venosus flow velocity waveforms in twin to twin transfusion syndrome treated with laser surgery.
MedLine Citation:
PMID:  24975921     Owner:  NLM     Status:  Publisher    
OBJECTIVES: To investigate time-related variables of ductus venosus (DV) flow velocity waveforms (FVW) in twin to twin transfusion syndrome (TTTS), comparing the results with reference ranges from normal singleton fetuses, and to evaluate the impact of laser surgery and prognostic factors.
METHODS: In 107 TTTS cases DV-FVWs of both, recipients and donors, were recorded 1 day before and 2 days after laser therapy. Time intervals for systolic (S) and early diastolic (D) peaks were retrospectively analyzed regarding acceleration time (acc-S for S, acc-D for D) and deceleration time (dec-S for S, dec-D for D), respectively. For each variable, z-scores were calculated.
RESULTS: Compared to reference ranges, all z-scores except dec-S of donors showed significant differences and the most striking differences were observed in longer dec-S of recipients (P < 0.001) and dec-D of donors (P < 0.001). Laser therapy showed significant impacts on dec-S and acc-D in recipients and on all variables in donors. Regarding the short term prognosis, acc-S and dec-S showed significant differences for the prediction of intrauterine fetal demise in donors (P = 0.009 and P = 0.011, respectively).
CONCLUSIONS: This study demonstrates that time-related variables of DV-FVWs may differentiate the characteristic hemodynamic changes caused by unbalanced blood volume between recipients and donors.
D Tachibana; P Glosemeyer; W Diehl; K Nakagawa; N Wada; Y Kurihara; M Fukui; M Koyama; K Hecher
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2014-6-27
Journal Detail:
Title:  Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology     Volume:  -     ISSN:  1469-0705     ISO Abbreviation:  Ultrasound Obstet Gynecol     Publication Date:  2014 Jun 
Date Detail:
Created Date:  2014-6-30     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9108340     Medline TA:  Ultrasound Obstet Gynecol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
This article is protected by copyright. All rights reserved.
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