Document Detail


Time profile of abamectin and doramectin excretion and degradation in sheep faeces.
MedLine Citation:
PMID:  16519977     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We studied abamectin and doramectin excretion and their degradation in sheep faeces under field conditions on pasture after a single subcutaneous dose (0.2mg/kg body weight). In the excretion experiment, maximal abamectin concentration (1277 ng/g dry faeces) was detected on day 3, while doramectin concentration showed two peaks (2186 and 1780 ng/g dry faeces on days 2 and 5, respectively). Both avermectins were excreted at approximately the same rate (k=0.23 day(-1) for abamectin and 0.19 day(-1) for doramectin). In the field, a rapid loss of abamectin and doramectin from sheep faeces was seen during the first 32 days after which concentrations remained constant at approximately 77 ng/g and 300 ng/g, respectively. The half life values (DT(50)) for abamectin and doramectin dissipation from sheep faeces were 23 and 22 days, respectively, during the first 32 days. Dissipation of both avermectins was strongly correlated with moisture content of the faeces.
Authors:
Lucija Kolar; Vesna Cerkvenik Flajs; Jernej Kuzner; Irena Marc; Milan Pogacnik; Andrej Bidovec; Cornelis A M van Gestel; Nevenka Kozuh Erzen
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2006-03-06
Journal Detail:
Title:  Environmental pollution (Barking, Essex : 1987)     Volume:  144     ISSN:  0269-7491     ISO Abbreviation:  Environ. Pollut.     Publication Date:  2006 Nov 
Date Detail:
Created Date:  2006-09-05     Completed Date:  2007-08-02     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8804476     Medline TA:  Environ Pollut     Country:  England    
Other Details:
Languages:  eng     Pagination:  197-202     Citation Subset:  IM    
Affiliation:
Institute of Physiology, Pharmacology and Toxicology, Veterinary Faculty, University of Ljubljana, Gerbiceva 60, SI-1000 Ljubljana, Slovenia. lucija.kolar@vf.uni-lj.si <lucija.kolar@vf.uni-lj.si>
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MeSH Terms
Descriptor/Qualifier:
Animals
Anthelmintics / analysis*,  chemistry
Biodegradation, Environmental
Chromatography, High Pressure Liquid
Drug Residues / analysis*
Environmental Monitoring / methods
Environmental Pollution / adverse effects
Feces / chemistry*
Ivermectin / analogs & derivatives*,  analysis,  chemistry
Sheep Diseases / prevention & control
Sheep, Domestic / metabolism*
Time
Chemical
Reg. No./Substance:
0/Anthelmintics; 117704-25-3/doramectin; 70288-86-7/Ivermectin; 71751-41-2/abamectin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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