Document Detail


Time point expression of apoptosis regulatory proteins in a photochemically-induced focal cerebral ischemic rat brain.
MedLine Citation:
PMID:  22247913     Owner:  NLM     Status:  PubMed-not-MEDLINE    
Abstract/OtherAbstract:
Apoptosis after global or focal cerebral ischemia plays a crucial role in mediating cell death. In this study, we observed the time point expression of physiologic events involving apoptosis regulatory proteins after photochemically-induced focal cerebral ischemia in Sprague-Dawley rats. Protein expression was evaluated at days 1, 3, and 7 by Western blot. Bcl-2, Bax, caspase-3, and phosphorylated Akt (pAkt) activity markedly increased in the ischemic hemisphere in a time-dependent manner, not affected. The expression of Bcl-2, Bax, and caspase-3 was dramatically changed around day 3, whereas changes in pAkt expression occurred at day 1. Differential elevation of these apoptosis regulatory proteins at various time points indicates that different modes of cell death occur in photochemically-induced focal cerebral ischemia in a rat brain.
Authors:
Hyung-Seok Kim; Man-Seok Park; Jeong-Kil Lee; Hye-Jeong Kim; Jong-Tae Park; Min-Cheol Lee
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Publication Detail:
Type:  Journal Article     Date:  2011-12-26
Journal Detail:
Title:  Chonnam medical journal     Volume:  47     ISSN:  2233-7393     ISO Abbreviation:  Chonnam Med J     Publication Date:  2011 Dec 
Date Detail:
Created Date:  2012-01-16     Completed Date:  2012-10-02     Revised Date:  2013-05-29    
Medline Journal Info:
Nlm Unique ID:  101564659     Medline TA:  Chonnam Med J     Country:  Korea (South)    
Other Details:
Languages:  eng     Pagination:  144-9     Citation Subset:  -    
Affiliation:
Department of Forensic Medicine, Chonnam National University Medical School, Gwangju, Korea.
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