| Time-gated Cherenkov emission spectroscopy from linear accelerator irradiation of tissue phantoms. | |
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MedLine Citation:
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PMID: 22466192 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Radiation from a linear accelerator induces Cherenkov emission in tissue, which has recently been shown to produce biochemical spectral signatures that can be interpreted to estimate tissue hemoglobin and oxygen saturation or molecular fluorescence from reporters. The Cherenkov optical light levels are in the range of 10(-6) to 10(-9) W/cm2, which limits the practical utility of the signal in routine radiation therapy monitoring. However, due to the fact that the radiation is pulsed, gated-acquisition of the signal allows detection in the presence of ambient lighting, as is demonstrated here. This observation has the potential to significantly increase the value of Cherenkov emission spectroscopy during radiation therapy to monitor tissue molecular events. |
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Authors:
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Adam K Glaser; Rongxiao Zhang; Scott C Davis; David J Gladstone; Brian W Pogue |
Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural |
Journal Detail:
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Title: Optics letters Volume: 37 ISSN: 1539-4794 ISO Abbreviation: Opt Lett Publication Date: 2012 Apr |
Date Detail:
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Created Date: 2012-04-02 Completed Date: 2012-07-24 Revised Date: 2013-05-10 |
Medline Journal Info:
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Nlm Unique ID: 7708433 Medline TA: Opt Lett Country: United States |
Other Details:
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Languages: eng Pagination: 1193-5 Citation Subset: IM |
Affiliation:
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Thayer School of Engineering, Dartmouth College, Hanover, New Hampshire 03755, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Equipment Design Film Dosimetry / instrumentation* Hemoglobins / analysis Humans Monitoring, Physiologic / instrumentation* Neoplasms / radiotherapy* Oxygen / analysis* Particle Accelerators Phantoms, Imaging Scattering, Radiation Spectrum Analysis / instrumentation* |
| Grant Support | |
ID/Acronym/Agency:
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R01 CA109558/CA/NCI NIH HHS; R01 CA109558/CA/NCI NIH HHS; R01 CA120368/CA/NCI NIH HHS; R01 CA120368/CA/NCI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Hemoglobins; 7782-44-7/Oxygen |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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