Document Detail

Time-frequency mapping of R-R interval during complex partial seizures of temporal lobe origin.
MedLine Citation:
PMID:  10580303     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Activation of autonomic nervous system is common with seizures. No reliable biological markers of impending seizures have been found. Evaluation of autonomic changes might help elucidate the transition from interictal to ictal states. METHODS: We studied twelve patients (eight females, four males), from 19 to 62 years old with temporal lobe complex partial seizures (CPS). Dynamics of autonomic functions from oscillations in R-R interval (RRI) using time-frequency mapping based upon a Wigner distribution during pre-ictal, ictal and post-ictal periods. Oscillations in RRI at respiratory frequencies (RF) (> 0.1 Hz) are parasympathetically mediated and at nonrespiratory frequencies (NONRF) (0.01-0.09 Hz) are under combined sympathetic and parasympathetic influence. RESULTS: CPS evoked marked autonomic imbalance and tachycardia. Spectral powers at both RF_RRI and NONRF_RRI increased over the pre-ictal period. RF_RRI power then fell rapidly over the 30 s before seizure onset and remained markedly reduced during seizure (P < 0.004). NONRF_RRI power reached a maximum at seizure onset and declined to a minimum before the seizure cessation (P < 0.05). CONCLUSION: Time-frequency analysis revealed that autonomic activation hallmarks clinical seizure onset for several minutes. After combined parasympathetic and sympathetic activation, rapid parasympathetic withdrawal occurred approximately 30 s before the seizure, and sympathetic activation peaks at seizure onset. Therefore, the transition from interictal to ictal states is relatively long and associated with subclinical autonomic changes.
V Novak; A L Reeves; P Novak; P A Low; F W Sharbrough
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of the autonomic nervous system     Volume:  77     ISSN:  0165-1838     ISO Abbreviation:  J. Auton. Nerv. Syst.     Publication Date:  1999 Sep 
Date Detail:
Created Date:  2000-01-11     Completed Date:  2000-01-11     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8003419     Medline TA:  J Auton Nerv Syst     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  195-202     Citation Subset:  IM; S    
Department of Neurology, The Ohio State University, Columbus 43210, USA.
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MeSH Terms
Autonomic Nervous System / physiopathology*
Epilepsy, Temporal Lobe / physiopathology*
Heart Rate / physiology*
Middle Aged
Predictive Value of Tests
Seizures / physiopathology*
Signal Processing, Computer-Assisted
Time Factors

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