Document Detail


Time-of-flight secondary ion mass spectrometry (TOF-SIMS) imaging reveals cholesterol overload in the cerebral cortex of Alzheimer disease patients.
MedLine Citation:
PMID:  22956244     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Although cholesterol has been involved in the pathophysiology of Alzheimer disease (AD), its distribution in the cerebral cortex over the course of AD is unknown. We describe an original method to quantify cholesterol distribution using time-of-flight secondary ion mass spectrometry imaging. Cholesterol was unevenly distributed along the cortical thickness, being more abundant close to the white matter, in both control and AD cases. However, the mean cholesterol signal was significantly higher in the lower half of the cortex in AD samples compared to controls. This increase, when converted into cortical layers, was statistically significant for layers III and IV and did not reach significance in layers V + VI, the variability being too high at the interface between grey and white matter. The density of neurofibrillary tangles and of senile plaques was not statistically linked to the abundance of cholesterol. Cholesterol overload thus appears a new and independent alteration of AD cerebral cortex. The structure in which cholesterol accumulates and the mechanism of this accumulation remain to be elucidated.
Authors:
Adina N Lazar; Claudia Bich; Maï Panchal; Nicolas Desbenoit; Vanessa W Petit; David Touboul; Luce Dauphinot; Catherine Marquer; Olivier Laprévote; Alain Brunelle; Charles Duyckaerts
Related Documents :
16479944 - Dietary glycine concentration affects intestinal clostridium perfringens and lactobacil...
9181614 - Interaction of dietary flaxseed with coccidia infections in chickens.
18770204 - Experimental trichothecene mycotoxicosis produced in broiler chickens by fusarium sporo...
22956244 - Time-of-flight secondary ion mass spectrometry (tof-sims) imaging reveals cholesterol o...
8095884 - The effects of tannic acid on serum and liver lipids of raif and rico rats fed on high ...
8202444 - Atherosclerotic lesion development in hypercholesterolemic japanese quail following pro...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-9-7
Journal Detail:
Title:  Acta neuropathologica     Volume:  -     ISSN:  1432-0533     ISO Abbreviation:  Acta Neuropathol.     Publication Date:  2012 Sep 
Date Detail:
Created Date:  2012-9-7     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0412041     Medline TA:  Acta Neuropathol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Laboratoire de Neuropathologie Escourolle, Hôpital de la Salpêtrière, AP-HP, 47 Bd de l'Hôpital, 75013, Paris, France.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Curative effect of Terminalia chebula extract on acetic acid-induced experimental colitis: role of a...
Next Document:  Mapping of wheat mitochondrial mRNA termini and comparison with breakpoints in DNA homology among pl...