Document Detail

Time-of-flight magnetic resonance angiography at 7 Tesla.
MedLine Citation:
PMID:  18648256     Owner:  NLM     Status:  MEDLINE    
OBJECTIVES: Magnetic resonance angiography (MRA) is noninvasive and does not require the application of high doses of contrast agents, and thus is used in the clinical routine for evaluation of cerebrovascular diseases, eg, aneurysm and arteriovenous malformations. However, more subtle microvascular disease usually cannot be seen with the resolution capabilities of standard field strength MRA. The purpose of this study was to evaluate the ability of 7-T time-of-flight (ToF) MRA to depict the arterial brain vasculature and to compare the results to data from 1.5 T and 3 T. MATERIALS AND METHODS: The study was IRB approved and complied with The Health Insurance Portability and Accountability Act. All subjects gave written informed consent. Eight healthy volunteers (age: 36 +/- 10 years; 3 female, 5 male) were investigated using ToF MRA at 7 T, 3 T, and 1.5 T. Signal intensities of the large, primary vessels of the Circle of Willis were measured and signal-to-noise ratios were calculated. Visibility of smaller arteries was evaluated. RESULTS: The results show that ultrahigh field allows depiction of the large vessels of the Circle of Willis. Although it provides only small increases in signal-to-noise ratios for these vessels, compared with 1.5 T and 3 T, it additionally demonstrates considerably more first- and second-order branches. CONCLUSIONS: Because of its considerably enhanced potential to depict vessels of the Circle of Willis and its first- and second-order branches, ToF MRA at 7 T may become an important tool in future neuroradiology research and clinical care.
Johannes T Heverhagen; Eric Bourekas; Steffen Sammet; Michael V Knopp; Petra Schmalbrock
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Investigative radiology     Volume:  43     ISSN:  1536-0210     ISO Abbreviation:  Invest Radiol     Publication Date:  2008 Aug 
Date Detail:
Created Date:  2008-07-23     Completed Date:  2008-08-21     Revised Date:  2009-11-11    
Medline Journal Info:
Nlm Unique ID:  0045377     Medline TA:  Invest Radiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  568-73     Citation Subset:  IM    
Department of Radiology, The Ohio State University, Columbus, Ohio 43210-1250, USA.
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MeSH Terms
Cerebral Arteries / anatomy & histology*
Circle of Willis / anatomy & histology
Magnetic Resonance Angiography / methods*

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