Document Detail


Time estimation, knowledge of results and drug effects.
MedLine Citation:
PMID:  20034163     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
1. Knowledge of results can obscure the effects of a drug on time estimation, particularly when 10 s is estimated. The effect of such knowledge on 1 s estimation differs from the effect on 10 s estimation. 2. Secobarbital was the only drug which produced significant directional effects when tested with a nonparametric technique of moderate power. The effects of alcohol were found to be variable. The performance under d-amphetamine could not be discriminated from the performance under placebo. 3. Under the conditions of the present experiment, the one second estimation schedule appears more sensitive to drug effects than the 10 s schedule. 4. Timing responses were found to be sequentially dependent: within limits, successive interresponse times are positively correlated, a finding which warrants further study and elucidation.
Authors:
J Rutschmann; L Rubinstein
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Publication Detail:
Type:  Journal Article; Randomized Controlled Trial; Research Support, N.I.H., Extramural    
Journal Detail:
Title:  Journal of psychiatric research     Volume:  4     ISSN:  0022-3956     ISO Abbreviation:  J Psychiatr Res     Publication Date:  1966 Nov 
Date Detail:
Created Date:  2009-12-25     Completed Date:  2010-01-28     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0376331     Medline TA:  J Psychiatr Res     Country:  England    
Other Details:
Languages:  eng     Pagination:  107-14     Citation Subset:  IM    
Affiliation:
New York State Psychiatric Institute and Columbia University New York, New York, USA.
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MeSH Terms
Descriptor/Qualifier:
Amphetamine / pharmacology
Central Nervous System Depressants / pharmacology*
Central Nervous System Stimulants / pharmacology*
Conditioning, Operant / drug effects
Dextroamphetamine / pharmacology
Discrimination (Psychology) / drug effects*
Dose-Response Relationship, Drug
Ethanol / pharmacology
Feedback / drug effects*
Humans
Knowledge*
Male
Neuropsychological Tests
Reaction Time / drug effects
Reinforcement Schedule
Time Factors
Time Perception / drug effects*
Grant Support
ID/Acronym/Agency:
M-872//PHS HHS; MH 03616/MH/NIMH NIH HHS
Chemical
Reg. No./Substance:
0/Central Nervous System Depressants; 0/Central Nervous System Stimulants; 300-62-9/Amphetamine; 51-64-9/Dextroamphetamine; 64-17-5/Ethanol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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