| Time estimation, knowledge of results and drug effects. | |
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MedLine Citation:
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PMID: 20034163 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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1. Knowledge of results can obscure the effects of a drug on time estimation, particularly when 10 s is estimated. The effect of such knowledge on 1 s estimation differs from the effect on 10 s estimation. 2. Secobarbital was the only drug which produced significant directional effects when tested with a nonparametric technique of moderate power. The effects of alcohol were found to be variable. The performance under d-amphetamine could not be discriminated from the performance under placebo. 3. Under the conditions of the present experiment, the one second estimation schedule appears more sensitive to drug effects than the 10 s schedule. 4. Timing responses were found to be sequentially dependent: within limits, successive interresponse times are positively correlated, a finding which warrants further study and elucidation. |
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Authors:
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J Rutschmann; L Rubinstein |
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Publication Detail:
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Type: Journal Article; Randomized Controlled Trial; Research Support, N.I.H., Extramural |
Journal Detail:
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Title: Journal of psychiatric research Volume: 4 ISSN: 0022-3956 ISO Abbreviation: J Psychiatr Res Publication Date: 1966 Nov |
Date Detail:
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Created Date: 2009-12-25 Completed Date: 2010-01-28 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0376331 Medline TA: J Psychiatr Res Country: England |
Other Details:
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Languages: eng Pagination: 107-14 Citation Subset: IM |
Affiliation:
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New York State Psychiatric Institute and Columbia University New York, New York, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Amphetamine
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pharmacology Central Nervous System Depressants / pharmacology* Central Nervous System Stimulants / pharmacology* Conditioning, Operant / drug effects Dextroamphetamine / pharmacology Discrimination (Psychology) / drug effects* Dose-Response Relationship, Drug Ethanol / pharmacology Feedback / drug effects* Humans Knowledge* Male Neuropsychological Tests Reaction Time / drug effects Reinforcement Schedule Time Factors Time Perception / drug effects* |
| Grant Support | |
ID/Acronym/Agency:
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M-872//PHS HHS; MH 03616/MH/NIMH NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Central Nervous System Depressants; 0/Central Nervous System Stimulants; 300-62-9/Amphetamine; 51-64-9/Dextroamphetamine; 64-17-5/Ethanol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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