| Time domains of the hypoxic ventilatory response. | |
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MedLine Citation:
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PMID: 9716296 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The ventilatory response to hypoxia depends on the pattern and intensity of hypoxic exposure and involves several physiological mechanisms. These mechanisms differ in their effect (facilitation or depression) on different components of ventilation (tidal volume and frequency) and in their time course (seconds to years). Some mechanisms last long enough to affect future ventilatory responses to hypoxia, indicating 'memory' or functional plasticity in the ventilatory control system. A standard terminology is proposed to describe the different time domains of the hypoxic ventilatory response (HVR) and to promote integration of results from different experimental preparations and laboratories. In general, the neurophysiological and neurochemical basis for short time domains of the HVR (seconds and minutes) are understood better than longer time domains (days to years), primarily because short time domains are studied in the laboratory more easily. Understanding the mechanisms for different time domains of the HVR has important implications for both basic and clinical science. |
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Authors:
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F L Powell; W K Milsom; G S Mitchell |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.; Review |
Journal Detail:
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Title: Respiration physiology Volume: 112 ISSN: 0034-5687 ISO Abbreviation: Respir Physiol Publication Date: 1998 May |
Date Detail:
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Created Date: 1998-11-04 Completed Date: 1998-11-04 Revised Date: 2009-11-11 |
Medline Journal Info:
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Nlm Unique ID: 0047142 Medline TA: Respir Physiol Country: NETHERLANDS |
Other Details:
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Languages: eng Pagination: 123-34 Citation Subset: IM; S |
Affiliation:
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Department of Medicine and White Mountain Research Station University of California, San Diego, La Jolla 92093-0623, USA. fpowell@ucsd.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Acclimatization
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physiology Altitude Animals Anoxia / physiopathology* Carotid Sinus / innervation Electric Stimulation Humans Models, Biological Pulmonary Ventilation / physiology* Respiratory Mechanics / physiology Serotonin / physiology Time Factors |
| Grant Support | |
ID/Acronym/Agency:
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HL 07212/HL/NHLBI NIH HHS; HL 17731/HL/NHLBI NIH HHS; HL 36780/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
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50-67-9/Serotonin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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