Document Detail


Time domains of the hypoxic ventilatory response.
MedLine Citation:
PMID:  9716296     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The ventilatory response to hypoxia depends on the pattern and intensity of hypoxic exposure and involves several physiological mechanisms. These mechanisms differ in their effect (facilitation or depression) on different components of ventilation (tidal volume and frequency) and in their time course (seconds to years). Some mechanisms last long enough to affect future ventilatory responses to hypoxia, indicating 'memory' or functional plasticity in the ventilatory control system. A standard terminology is proposed to describe the different time domains of the hypoxic ventilatory response (HVR) and to promote integration of results from different experimental preparations and laboratories. In general, the neurophysiological and neurochemical basis for short time domains of the HVR (seconds and minutes) are understood better than longer time domains (days to years), primarily because short time domains are studied in the laboratory more easily. Understanding the mechanisms for different time domains of the HVR has important implications for both basic and clinical science.
Authors:
F L Powell; W K Milsom; G S Mitchell
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.; Review    
Journal Detail:
Title:  Respiration physiology     Volume:  112     ISSN:  0034-5687     ISO Abbreviation:  Respir Physiol     Publication Date:  1998 May 
Date Detail:
Created Date:  1998-11-04     Completed Date:  1998-11-04     Revised Date:  2009-11-11    
Medline Journal Info:
Nlm Unique ID:  0047142     Medline TA:  Respir Physiol     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  123-34     Citation Subset:  IM; S    
Affiliation:
Department of Medicine and White Mountain Research Station University of California, San Diego, La Jolla 92093-0623, USA. fpowell@ucsd.edu
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MeSH Terms
Descriptor/Qualifier:
Acclimatization / physiology
Altitude
Animals
Anoxia / physiopathology*
Carotid Sinus / innervation
Electric Stimulation
Humans
Models, Biological
Pulmonary Ventilation / physiology*
Respiratory Mechanics / physiology
Serotonin / physiology
Time Factors
Grant Support
ID/Acronym/Agency:
HL 07212/HL/NHLBI NIH HHS; HL 17731/HL/NHLBI NIH HHS; HL 36780/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
50-67-9/Serotonin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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