Document Detail

Time-dependent sensitization--possible implications for clinical psychopharmacology.
MedLine Citation:
PMID:  9832965     Owner:  NLM     Status:  MEDLINE    
Time-dependent sensitization (TDS) has been described in animal models over the past 20 years. It is a phenomenon that occurs in a variety of biological systems, and corresponds to the cellular and systems response to a foreign or stressful stimulus. The exposure to the stimulus triggers the responses typical of that particular biological system, which are progressively amplified with time. This phenomenon has potential major implications for clinical pharmacology. Some human studies have investigated this phenomenon to date. Antidepressant action, with its typical lag in the onset of effects, may be a fruitful paradigm to understand the relevance of TDS for psychopharmacological treatment. In this paper we review these emerging findings, and suggest that clinical pharmacology research should investigate this process further in expanded human studies.
S M Antelman; J C Soares; S Gershon
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.; Review    
Journal Detail:
Title:  Behavioural pharmacology     Volume:  8     ISSN:  0955-8810     ISO Abbreviation:  Behav Pharmacol     Publication Date:  1997 Nov 
Date Detail:
Created Date:  1998-12-29     Completed Date:  1998-12-29     Revised Date:  2009-07-07    
Medline Journal Info:
Nlm Unique ID:  9013016     Medline TA:  Behav Pharmacol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  505-14; discussion 515-22     Citation Subset:  IM    
Department of Psychiatry, University of Pittsburgh School of Medicine, PA 15213, USA.
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MeSH Terms
Psychotropic Drugs / pharmacology*
Time Factors
Grant Support
Reg. No./Substance:
0/Psychotropic Drugs

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