| Time-dependent sensitization--possible implications for clinical psychopharmacology. | |
| | |
MedLine Citation:
|
PMID: 9832965 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Time-dependent sensitization (TDS) has been described in animal models over the past 20 years. It is a phenomenon that occurs in a variety of biological systems, and corresponds to the cellular and systems response to a foreign or stressful stimulus. The exposure to the stimulus triggers the responses typical of that particular biological system, which are progressively amplified with time. This phenomenon has potential major implications for clinical pharmacology. Some human studies have investigated this phenomenon to date. Antidepressant action, with its typical lag in the onset of effects, may be a fruitful paradigm to understand the relevance of TDS for psychopharmacological treatment. In this paper we review these emerging findings, and suggest that clinical pharmacology research should investigate this process further in expanded human studies. |
| | |
Authors:
|
S M Antelman; J C Soares; S Gershon |
Related Documents
:
|
16504765 - Multivariable modeling of radiotherapy outcomes, including dose-volume and clinical fac... 11212625 - The morton-massaro law of information integration: implications for models of perception. 3719065 - The impact of litter effects on dose-response modeling in teratology. 21995025 - Apparent intravoxel fibre population dispersion (fpd) using spherical harmonics. 15697715 - Cluster-weighted modeling: estimation of the lyapunov spectrum in driven systems. 19737395 - Procov: maximum likelihood estimation of protein phylogeny under covarion models and si... |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.; Review |
Journal Detail:
|
Title: Behavioural pharmacology Volume: 8 ISSN: 0955-8810 ISO Abbreviation: Behav Pharmacol Publication Date: 1997 Nov |
Date Detail:
|
Created Date: 1998-12-29 Completed Date: 1998-12-29 Revised Date: 2009-07-07 |
Medline Journal Info:
|
Nlm Unique ID: 9013016 Medline TA: Behav Pharmacol Country: ENGLAND |
Other Details:
|
Languages: eng Pagination: 505-14; discussion 515-22 Citation Subset: IM |
Affiliation:
|
Department of Psychiatry, University of Pittsburgh School of Medicine, PA 15213, USA. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Humans Psychopharmacology* Psychotropic Drugs / pharmacology* Time Factors |
| Grant Support | |
ID/Acronym/Agency:
|
DA09163/DA/NIDA NIH HHS |
| Chemical | |
Reg. No./Substance:
|
0/Psychotropic Drugs |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Animal models of 'anxiety': where next?
Next Document: The forced swimming test as a model for core and component behavioral effects of antidepressant drug...