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Time-dependent effect of in utero inflammation: a longitudinal study in rats.
MedLine Citation:
PMID:  23297691     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Objective: To determine the impact of the duration of fetal exposure to inflammation on the neurological outcome of pups. Method: Time-pregnant Sprague-Dawley rats (n=32) received intraperitoneal injection of lipopolysaccharides (LPS; 500µg/kg), or an equivalent volume of vehicle 3h, 6h, 12h and 24h before C-section. Maternal serum and amniotic fluid were tested for cytokines. Motor activity of resuscitated pups (n=58) was analyzed using the open field test (20 days). Brains were collected for histopathological examination. Results: Perinatal mortality increased with the duration of fetal exposure to LPS. All parameters tested with the open field test were lower in the LPS 12h exposure group compared to the control group (p<0.05). Tissue inhibitor of metalloproteinase 1 (TIMP-1) was statistically increased in maternal blood 3h, 6 h and 12 h after LPS injection (p < 0.05 vs. control). Conclusion: A threshold of duration of exposure to inflammation is demonstrated, before which delivery should be performed in order to prevent brain damage.
Authors:
Roy-Lacroix Marie-Ève; Maxime Guérard; Maryse Berthiaume; Rola-Pleszczynski Marek; Crous-Tsanaclis Ana-Maria; Jean-Charles Pasquier
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-1-9
Journal Detail:
Title:  The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians     Volume:  -     ISSN:  1476-4954     ISO Abbreviation:  J. Matern. Fetal. Neonatal. Med.     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2013-1-9     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101136916     Medline TA:  J Matern Fetal Neonatal Med     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Sherbrooke, Québec, Canada.
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