Document Detail


Time-dependent changes of lumped and rate constants in the deoxyglucose method in experimental cerebral ischemia.
MedLine Citation:
PMID:  3654804     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Time-dependent changes in the lumped and rate constants in a bilateral middle cerebral artery (MCA) occlusion in cats were evaluated. These variables were measured in 11 cats after a sham operation, in five after a 1-h occlusion, in two after a 2-h occlusion, in five after a 4-h occlusion, and in four after a 16-h occlusion. The time course of the cerebral tissue radioactivity [Ci* (t)] was monitored by external coincidence counting during a programmed infusion of [18F]2-fluorodeoxyglucose (FDG). Arterial plasma concentration [Cp* (t)] of tracer was kept constant during the first 45 min. Comparison of k2* and k3* in the sham-operated group, estimated by external coincidence counting, and by the ratio of extraction fractions of glucose and [18F]2-FDG, demonstrated no significant difference between these rate constants in these two groups of animals. The rate and lumped constants were also estimated from Ci* (t) and Cp* (t), as well as from the ratio of extraction fractions of glucose and [18F]2-FDG, respectively, in the MCA occlusion group. Significant decrease in k3* was observed after 1 h of occlusion (20% lower than in the sham operation, p less than 0.05); in k1* decrease occurred within 4 h of occlusion (21% lower than in the sham operation, p less than 0.05). However, decrease in k2* was observed only after 16 h of occlusion (26% lower than in the sham operation, p less than 0.05). Namely, decrease of rate constants occurred first in k3* then in k1* and k2*.(ABSTRACT TRUNCATED AT 250 WORDS)
Authors:
H Nakai; Y L Yamamoto; M Diksic; H Matsuda; E Takara; E Meyer; C Redies
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism     Volume:  7     ISSN:  0271-678X     ISO Abbreviation:  J. Cereb. Blood Flow Metab.     Publication Date:  1987 Oct 
Date Detail:
Created Date:  1987-11-13     Completed Date:  1987-11-13     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8112566     Medline TA:  J Cereb Blood Flow Metab     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  640-8     Citation Subset:  IM    
Affiliation:
Cone Neurosurgical Research Laboratory, Montreal Neurological Institute, McGill University, Quebec, Canada.
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MeSH Terms
Descriptor/Qualifier:
Animals
Arterial Occlusive Diseases / complications
Arteries
Brain Ischemia / etiology,  metabolism*,  physiopathology
Cats
Cerebral Arterial Diseases / complications
Cerebrovascular Circulation
Deoxy Sugars / metabolism*
Deoxyglucose / blood,  metabolism*
Kinetics
Methods
Models, Neurological
Time Factors
Chemical
Reg. No./Substance:
0/Deoxy Sugars; 154-17-6/Deoxyglucose

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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