| Time-dependent changes in lipid metabolism in mice with methionine choline deficiency-induced fatty liver disease. | |
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MedLine Citation:
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PMID: 22083307 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Methionine and choline-deficient diet (MCD)-induced fatty liver is one of the best-studied animal models of fatty liver disease. The present study was performed to clarify the relative contributions of individual lipid metabolic pathways to the pathogenesis of MCD-induced fatty liver. Hepatic lipogenesis mediated by the sterol regulatory element-binding protein (SREBP-1c) was increased at 1 week, but not at 6 weeks, of MCD feeding. On the other hand, (14)C-palmitate oxidation did not change at 1 week, but significantly decreased at 6 weeks. This decrease was associated with increased expression of fatty acid translocase, a key enzyme involved in fatty acid uptake. Expression of endoplasmic reticulum stress markers was increased in mice given MCD for both 1 and 6 weeks. These findings suggest the presence of time-dependent differences in lipid metabolism in MCD-induced fatty liver disease: SREBP-1c-mediated lipogenesis is important in the early stages of fatty liver disease, whereas increased fatty acid uptake and decreased fatty acid oxidation become more important in the later stages. |
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Authors:
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Han-Sol Park; Byeong Hwan Jeon; Sung Hoon Woo; Jaechan Leem; Jung Eun Jang; Min Sock Cho; In-Sun Park; Ki-Up Lee; Eun Hee Koh |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-11-11 |
Journal Detail:
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Title: Molecules and cells Volume: - ISSN: 0219-1032 ISO Abbreviation: - Publication Date: 2011 Nov |
Date Detail:
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Created Date: 2011-11-15 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9610936 Medline TA: Mol Cells Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Asan Institute for Life Sciences, University of Ulsan College of Medicine, Seoul, 138-736, Korea. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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