Document Detail


Time-dependent changes in lipid metabolism in mice with methionine choline deficiency-induced fatty liver disease.
MedLine Citation:
PMID:  22083307     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Methionine and choline-deficient diet (MCD)-induced fatty liver is one of the best-studied animal models of fatty liver disease. The present study was performed to clarify the relative contributions of individual lipid metabolic pathways to the pathogenesis of MCD-induced fatty liver. Hepatic lipogenesis mediated by the sterol regulatory element-binding protein (SREBP-1c) was increased at 1 week, but not at 6 weeks, of MCD feeding. On the other hand, (14)C-palmitate oxidation did not change at 1 week, but significantly decreased at 6 weeks. This decrease was associated with increased expression of fatty acid translocase, a key enzyme involved in fatty acid uptake. Expression of endoplasmic reticulum stress markers was increased in mice given MCD for both 1 and 6 weeks. These findings suggest the presence of time-dependent differences in lipid metabolism in MCD-induced fatty liver disease: SREBP-1c-mediated lipogenesis is important in the early stages of fatty liver disease, whereas increased fatty acid uptake and decreased fatty acid oxidation become more important in the later stages.
Authors:
Han-Sol Park; Byeong Hwan Jeon; Sung Hoon Woo; Jaechan Leem; Jung Eun Jang; Min Sock Cho; In-Sun Park; Ki-Up Lee; Eun Hee Koh
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2011-11-11
Journal Detail:
Title:  Molecules and cells     Volume:  32     ISSN:  0219-1032     ISO Abbreviation:  Mol. Cells     Publication Date:  2011 Dec 
Date Detail:
Created Date:  2011-12-30     Completed Date:  2012-04-20     Revised Date:  2014-02-20    
Medline Journal Info:
Nlm Unique ID:  9610936     Medline TA:  Mol Cells     Country:  Korea (South)    
Other Details:
Languages:  eng     Pagination:  571-7     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Choline Deficiency / complications*
DNA-Binding Proteins / genetics,  metabolism
Diacylglycerol O-Acyltransferase / genetics,  metabolism
Endoplasmic Reticulum Stress
Eukaryotic Initiation Factor-2 / metabolism
Fatty Acid Synthases / genetics,  metabolism
Fatty Acid Transport Proteins / genetics,  metabolism
Fatty Acids / metabolism
Fatty Liver / etiology,  metabolism*
Fibrosis
Gene Expression
Glycerol-3-Phosphate O-Acyltransferase / genetics,  metabolism
Lipid Mobilization / genetics*
Lipogenesis / genetics
Liver / metabolism,  pathology
Membrane Proteins / genetics,  metabolism
Methionine / deficiency*
Mice
Mice, Inbred C57BL
Phosphorylation
Sterol Regulatory Element Binding Protein 1 / genetics,  metabolism
Transcription Factor CHOP / metabolism
Transcription Factors / genetics,  metabolism
Chemical
Reg. No./Substance:
0/DNA-Binding Proteins; 0/Ddit3 protein, mouse; 0/Eukaryotic Initiation Factor-2; 0/Fatty Acid Transport Proteins; 0/Fatty Acids; 0/Insig2 protein, mouse; 0/Membrane Proteins; 0/Srebf1 protein, mouse; 0/Sterol Regulatory Element Binding Protein 1; 0/Transcription Factors; 0/regulatory factor X transcription factors; 147336-12-7/Transcription Factor CHOP; AE28F7PNPL/Methionine; EC 2.3.1.15/Glycerol-3-Phosphate O-Acyltransferase; EC 2.3.1.20/DGAT2 protein, mouse; EC 2.3.1.20/Diacylglycerol O-Acyltransferase; EC 2.3.1.85/Fatty Acid Synthases
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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