Document Detail


Time-dependent changes in the expression of lymphocyte and monocyte cell adhesion molecules after meals of different composition.
MedLine Citation:
PMID:  20691129     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The objective of the present study was to compare the acute effect of meals of different composition on the expression of adhesion molecules that play a key role in leucocyte trafficking. A total of twenty apparently healthy subjects randomly consumed three isoenergetic meals 1 week apart: enriched in carbohydrates (CHO), enriched in monounsaturated fat and enriched in saturated fat. Blood samples were obtained before the meals and at 2, 4, 6, 8 and 10 h after meal ingestion. Samples were analysed for LDL resistance to Cu-mediated oxidation and for the surface expression on peripheral blood mononuclear cells (PBMC) of CD62L, CD162, CD11a, CD11b, CD49d and CD54 by flow cytometry. The present results showed that there were no changes in LDL susceptibility to oxidation within and among the meals. After the CHO-enriched meal, there was a time-dependent increased expression of CD162, CD49d, CD11a and CD54 on PBMC that returned to basal values after 8-10 h. These changes were significantly greater than the ones observed after the consumption of the monounsaturated fat- and the saturated fat-enriched meals and were more evident in lymphocytes than in monocytes. In conclusion, acute ingestion of a CHO-enriched meal induces higher increases of lymphocyte activation markers than fat-enriched meals. These results suggest that long-term consumption of CHO-enriched diets may be associated with a sustained pro-inflammatory state.
Authors:
Esther Torrecilla; Miguel González-Muñoz; Carlos Lahoz; Jose Mostaza
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Publication Detail:
Type:  Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't     Date:  2010-08-09
Journal Detail:
Title:  The British journal of nutrition     Volume:  104     ISSN:  1475-2662     ISO Abbreviation:  Br. J. Nutr.     Publication Date:  2010 Dec 
Date Detail:
Created Date:  2010-12-01     Completed Date:  2011-01-04     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0372547     Medline TA:  Br J Nutr     Country:  England    
Other Details:
Languages:  eng     Pagination:  1650-4     Citation Subset:  IM    
Affiliation:
Atherosclerosis Unit, Hospital Carlos III, Madrid, Spain.
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MeSH Terms
Descriptor/Qualifier:
Adult
Antigens, CD / blood*
Cell Adhesion Molecules / blood*
Cholesterol, LDL / blood
Cross-Over Studies
Dietary Carbohydrates / pharmacology*
Dietary Fats / pharmacology*
Fatty Acids / pharmacology*
Fatty Acids, Monounsaturated / pharmacology
Female
Flow Cytometry
Humans
Lymphocytes / drug effects*
Male
Monocytes / drug effects*
Chemical
Reg. No./Substance:
0/Antigens, CD; 0/Cell Adhesion Molecules; 0/Cholesterol, LDL; 0/Dietary Carbohydrates; 0/Dietary Fats; 0/Fatty Acids; 0/Fatty Acids, Monounsaturated

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