Document Detail

Time-dependent changes of amino acids in the serum, liver, brain and urine of rats administered with theanine.
MedLine Citation:
PMID:  10361674     Owner:  NLM     Status:  MEDLINE    
Time-dependent changes of theanine (gamma-glutamylethylamide) and other amino acids in various tissues of rats were investigated during the 24 hrs after theanine administration. When theanine (4 g/kg of body weight) was intragastrically administered to rats, the concentrations of theanine in the serum, liver and brain were significantly increased 1 hr after its administration, and thereafter gradually decreased, but reached the maximum level in the brain after 5 hrs. Theanine in these tissues had completely disappeared 24 hrs after its administration. In contrast, the administration of theanine resulted in the concentrations of theanine, urea, ethylamine and glutamic acid in the urine being significantly enhanced. These results suggest that theanine might be degraded via glutamic acid.
T Terashima; J Takido; H Yokogoshi
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Bioscience, biotechnology, and biochemistry     Volume:  63     ISSN:  0916-8451     ISO Abbreviation:  Biosci. Biotechnol. Biochem.     Publication Date:  1999 Apr 
Date Detail:
Created Date:  1999-07-26     Completed Date:  1999-07-26     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  9205717     Medline TA:  Biosci Biotechnol Biochem     Country:  JAPAN    
Other Details:
Languages:  eng     Pagination:  615-8     Citation Subset:  IM    
School of Food and Nutritional Sciences, University of Shizuoka, Japan.
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MeSH Terms
Amino Acids / blood,  metabolism*,  urine
Brain Chemistry / drug effects*
Glutamates / pharmacology*
Liver / drug effects,  metabolism*
Rats, Wistar
Time Factors
Reg. No./Substance:
0/Amino Acids; 0/Glutamates; 3081-61-6/theanine

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