| Time-dependent change in the effect of probucol in subjects with elevated cholesterol. | |
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MedLine Citation:
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PMID: 1425896 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A time-dependent change in the cholesterol-lowering effect of probucol has been evaluated in 20 subjects with elevated cholesterol. Probucol 500 mg was given once daily at 07.00 h (day trial) or 19.00 h (night trial) for 3 months according to a crossover design. Fasting blood samples were obtained during the control period and at the end of each treatment period. Serum concentrations of total and HDL-cholesterol were significantly decreased by both the treatments with probucol [total cholesterol (mmol.l-1): control 6.58; day trial 5.41; night trial 5.10; HDL-cholesterol (mmol.l-1): control 1.35; day trial 1.06; night trial 0.96]. These parameters were significantly lower in the night trial than in the day trial. The data indicate that the cholesterol-lowering effect of probucol varies with its time of administration in subjects with elevated cholesterol. |
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Authors:
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A Fujimura; K Ohashi; A Ebihara |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: European journal of clinical pharmacology Volume: 43 ISSN: 0031-6970 ISO Abbreviation: Eur. J. Clin. Pharmacol. Publication Date: 1992 |
Date Detail:
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Created Date: 1992-12-01 Completed Date: 1992-12-01 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 1256165 Medline TA: Eur J Clin Pharmacol Country: GERMANY |
Other Details:
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Languages: eng Pagination: 299-301 Citation Subset: IM |
Affiliation:
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Department of Clinical Pharmacology, Jichi Medical School, Tochigi, Japan. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aged Aged, 80 and over Cholesterol / blood Cholesterol, HDL / blood Female Humans Hypercholesterolemia / blood, drug therapy* Male Middle Aged Probucol / pharmacokinetics, therapeutic use* Time Factors |
| Chemical | |
Reg. No./Substance:
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0/Cholesterol, HDL; 23288-49-5/Probucol; 57-88-5/Cholesterol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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