Document Detail

Time-dependent adaptation in the hemodynamic response to hypoxia.
MedLine Citation:
PMID:  19013546     Owner:  NLM     Status:  MEDLINE    
In rats, acute exposure to hypoxia causes a decrease in mean arterial pressure (MAP) caused by a predominance of hypoxic vasodilation over chemoreflex-induced vasoconstriction. We previously demonstrated that exposure to chronic intermittent hypoxia (CIH) impairs hypoxic vasodilation in isolated resistance arteries; therefore, we hypothesized that the acute systemic hemodynamic responses to hypoxia would be altered by exposure to CIH. To test this hypothesis, rats were exposed to CIH for 14 days. Heart rate (HR) and MAP were monitored by telemetry. On the first day of CIH exposure, acute episodes of hypoxia caused a decrease in MAP (-9+/-5 mmHg) and an increase in HR (+45+/-4 beats/min). On the 14th day of CIH exposure the depressor response was attenuated (-4+/-1mmHg; 44% of the day 1 response) and the tachycardia was enhanced (+68+/-2 beats/min; 151% of the day 1 response). The observed time-dependent modulation of the acute hemodynamic responses to hypoxia may reflect important changes in neurocirculatory regulation that contribute to CIH-induced hypertension.
Noah J Marcus; E Burt Olson; Cynthia E Bird; Nathan R Philippi; Barbara J Morgan
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2008-11-01
Journal Detail:
Title:  Respiratory physiology & neurobiology     Volume:  165     ISSN:  1569-9048     ISO Abbreviation:  Respir Physiol Neurobiol     Publication Date:  2009 Jan 
Date Detail:
Created Date:  2008-12-26     Completed Date:  2009-03-24     Revised Date:  2010-09-23    
Medline Journal Info:
Nlm Unique ID:  101140022     Medline TA:  Respir Physiol Neurobiol     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  90-6     Citation Subset:  IM    
John Rankin Laboratory of Pulmonary Medicine, Department of Kinesiology, Respiratory Neurobiology Training Program, University of Wisconsin, Madison, WI, USA.
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MeSH Terms
Adaptation, Physiological / physiology*
Analysis of Variance
Anoxia / physiopathology*
Blood Pressure / physiology
Circadian Rhythm / physiology
Heart Rate / physiology
Hematocrit / methods
Hemodynamics / physiology*
Rats, Sprague-Dawley
Time Factors
Grant Support

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