| Time-dependent adaptation in the hemodynamic response to hypoxia. | |
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MedLine Citation:
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PMID: 19013546 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In rats, acute exposure to hypoxia causes a decrease in mean arterial pressure (MAP) caused by a predominance of hypoxic vasodilation over chemoreflex-induced vasoconstriction. We previously demonstrated that exposure to chronic intermittent hypoxia (CIH) impairs hypoxic vasodilation in isolated resistance arteries; therefore, we hypothesized that the acute systemic hemodynamic responses to hypoxia would be altered by exposure to CIH. To test this hypothesis, rats were exposed to CIH for 14 days. Heart rate (HR) and MAP were monitored by telemetry. On the first day of CIH exposure, acute episodes of hypoxia caused a decrease in MAP (-9+/-5 mmHg) and an increase in HR (+45+/-4 beats/min). On the 14th day of CIH exposure the depressor response was attenuated (-4+/-1mmHg; 44% of the day 1 response) and the tachycardia was enhanced (+68+/-2 beats/min; 151% of the day 1 response). The observed time-dependent modulation of the acute hemodynamic responses to hypoxia may reflect important changes in neurocirculatory regulation that contribute to CIH-induced hypertension. |
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Authors:
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Noah J Marcus; E Burt Olson; Cynthia E Bird; Nathan R Philippi; Barbara J Morgan |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural Date: 2008-11-01 |
Journal Detail:
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Title: Respiratory physiology & neurobiology Volume: 165 ISSN: 1569-9048 ISO Abbreviation: Respir Physiol Neurobiol Publication Date: 2009 Jan |
Date Detail:
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Created Date: 2008-12-26 Completed Date: 2009-03-24 Revised Date: 2010-09-23 |
Medline Journal Info:
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Nlm Unique ID: 101140022 Medline TA: Respir Physiol Neurobiol Country: Netherlands |
Other Details:
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Languages: eng Pagination: 90-6 Citation Subset: IM |
Affiliation:
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John Rankin Laboratory of Pulmonary Medicine, Department of Kinesiology, Respiratory Neurobiology Training Program, University of Wisconsin, Madison, WI, USA. nmarcus@wisc.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adaptation, Physiological
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physiology* Analysis of Variance Animals Anoxia / physiopathology* Blood Pressure / physiology Circadian Rhythm / physiology Heart Rate / physiology Hematocrit / methods Hemodynamics / physiology* Male Rats Rats, Sprague-Dawley Time Factors |
| Grant Support | |
ID/Acronym/Agency:
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HL-074072/HL/NHLBI NIH HHS; R01 HL074072-02/HL/NHLBI NIH HHS |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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