Document Detail

Time-dependency of sensory evoked potentials in comatose cardiac arrest survivors.
MedLine Citation:
PMID:  11511943     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To assess the validity of early sensory evoked potential (SEP) recording for reliable outcome prediction in comatose cardiac arrest survivors within 48 h after restoration of spontaneous circulation (ROSC). DESIGN AND SETTING: Prospective cohort study in a medical intensive care unit of a university hospital. PATIENTS: Twenty-five comatose, mechanically ventilated patients following cardiopulmonary resuscitation MEASUREMENTS AND RESULTS: Median nerve short- and long-latency SEP were recorded 4, 12, 24, and 48 h after ROSC. Cortical N20 peak latency and cervicomedullary conduction time decreased (improved) significantly between 4, 12, and 24 h after resuscitation in 22 of the enrolled patients. There was no further change in short-latency SEP at 48 h. The cortical N70 peak was initially detectable in seven patients. The number of patients with increased N70 peak increased to 11 at 12 h and 14 at 24 h; there was no further change at 48 h. Specificity of the N70 peak latency (critical cutoff 130 ms) increased from 0.43 at 4 h to 1.0 at 24 h after ROSC. Sensitivity decreased from 1.0 at 4 h to 0.83 at 24 h after ROSC. CONCLUSION: Within 24 h after ROSC there was a significant improvement in SEP. Therefore we recommend allowing a period of at least 24 h after cardiopulmonary resuscitation for obtaining a reliable prognosis based on SEP.
A Gendo; L Kramer; M Häfner; G C Funk; C Zauner; F Sterz; M Holzer; E Bauer; C Madl
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Intensive care medicine     Volume:  27     ISSN:  0342-4642     ISO Abbreviation:  Intensive Care Med     Publication Date:  2001 Aug 
Date Detail:
Created Date:  2001-08-20     Completed Date:  2001-11-01     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7704851     Medline TA:  Intensive Care Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1305-11     Citation Subset:  IM    
Department of Internal Medicine IV, Intensive Care Unit 13 H1, University of Vienna, Währinger Gürtel 18-20, 1090 Vienna, Austria.
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MeSH Terms
Aged, 80 and over
Analysis of Variance
Austria / epidemiology
Cardiopulmonary Resuscitation
Coma / diagnosis*,  etiology,  mortality
Evoked Potentials, Somatosensory*
Heart Arrest / complications*,  mortality
Middle Aged
Predictive Value of Tests
Prospective Studies
Sensitivity and Specificity
Time Factors

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