| Time course study on the effects of iodinated contrast medium on intrarenal water transport function using diffusion-weighted MRI. | |
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MedLine Citation:
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PMID: 22247072 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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PURPOSE: To assess the effects of intravenous-injected iodinated contrast medium (CM) on intrarenal water diffusion using noninvasive diffusion-weighted MRI (DW-MRI). MATERIALS AND METHODS: Ten New Zealand White rabbits were randomized to receive a 6 mL/kg body weight intravenous injection of clinically used iopamidol-370 (n = 7) or an equivalent amount of 0.9% physiological saline (n = 3). A sequential DW-MRI was performed to estimate the intrarenal apparent diffusion coefficient (ADC) at 24 h before and 1 h, 24 h, 48 h, and 72 h after administration. RESULTS: Iopamidol produced a progressive ADC reduction in inner stripes of the renal outer medulla (IS) by 13.92% (P = 0.05) at 1 h, 17.52% (P = 0.02) at 24 h, 20.23% (P = 0.01) at 48 h and 16.31% (P = 0.04) at 72 h after injection. Cortical ADC was decreased by 14.14% (P = 0.01) at 48 h and 14.12% (P = 0.01) at 72 h after injection. Iopamidol produced slight decrease of ADCs in outer stripes of the outer medulla (OS) and inner medulla (IM) of kidney but without statistical difference. In control group, no significant ADC changes was observed in each anatomic compartment due to saline injection (P > 0.05). CONCLUSION: As demonstrated by DW-MRI, intravenous iopamidol injection resulted in a successive reduction of intrarenal water diffusion, particularly in IS of kidney. This MR technique may be used as a noninvasive tool to perform a time course study of the pathogenesis associated with contrast-induced nephropathy (CIN). J. Magn. Reson. Imaging 2012;. © 2012 Wiley Periodicals, Inc. |
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Authors:
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Jing Wang; Yudong Zhang; Xuedong Yang; Xiaoying Wang; Jue Zhang; Jing Fang; Xuexiang Jiang |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-1-13 |
Journal Detail:
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Title: Journal of magnetic resonance imaging : JMRI Volume: - ISSN: 1522-2586 ISO Abbreviation: - Publication Date: 2012 Jan |
Date Detail:
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Created Date: 2012-1-16 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9105850 Medline TA: J Magn Reson Imaging Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2012 Wiley Periodicals, Inc. |
Affiliation:
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Academy for Advanced Interdisciplinary Studies, Peking University, Beijing, China. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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