| Time course and sensitivity of secretin-stimulated pancreatic secretion and blood flow in the anesthetized dog. | |
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MedLine Citation:
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PMID: 441678 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Time-effect relationship and sensitivity of pancreatic exocrine secretion and pancreatic blood flow were established, to test the supposition that blood flow to the pancreas is controlled by the secretory process. Pancreatic exocrine secretion rate was stimulated by incremental iv doses of secretin (Karolinska, 0.001--4 U/kg) in pentobarbital anesthetized dogs. Arterial pancreatic blood flow was measured by electromagnetic flowmeters; secretion rate was determined by measurement of frequency of consecutive secretory drops. Exocrine secretion rate and blood flow increased markedly. Secretion responded at a dose level 3-7 times lower than blood flow did. So at low secretory performance, the pancreas seemed to be well provided with basal blood supply. At moderate and high secretory levels blood flow did increase, but the flow increase was seen 16-22 sec before the secretion increase. So the additional support of blood flow in the secretory process occurred during the cellular preparation and during the start of the secretion increase. This suggests that secretion increase and blood flow increase are mediated by independent processes or receptors, but these processes seem to cooperate in processing the pancreatic juice. |
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Authors:
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H J Beijer; F A Brouwer; G A Charbon |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Scandinavian journal of gastroenterology Volume: 14 ISSN: 0036-5521 ISO Abbreviation: Scand. J. Gastroenterol. Publication Date: 1979 |
Date Detail:
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Created Date: 1979-07-25 Completed Date: 1979-07-25 Revised Date: 2003-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0060105 Medline TA: Scand J Gastroenterol Country: NORWAY |
Other Details:
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Languages: eng Pagination: 295-300 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Blood Pressure / drug effects Dogs Female Male Pancreas / blood supply*, secretion Pancreatic Juice / secretion* Regional Blood Flow / drug effects Secretin / pharmacology* Secretory Rate / drug effects Time Factors |
| Chemical | |
Reg. No./Substance:
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1393-25-5/Secretin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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