Document Detail


Time course and role of the pineal gland in photoperiod control of innate immune cell functions in male Siberian hamsters.
MedLine Citation:
PMID:  15748952     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The time course of select phagocyte and natural killer activities to short days was determined. In advance of testes regression, circulating granulocyte and monocyte cell numbers in hamsters decreased while lymphocyte numbers increased; phagocytosis and oxidative burst activity also decreased. To determine whether the pineal gland influences these innate immune cell functions, hamsters were exposed to constant light. Photoperiod control of testes weight and basal oxidative burst activity was abolished by treatment with constant light; other phagocyte activities and leukocyte proportions in circulation were not affected. The findings suggest that photoperiod and pineal gland function may regulate certain innate immune activities.
Authors:
Steven M Yellon; Kiam Kim; Allison R Hadley; Long T Tran
Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Journal of neuroimmunology     Volume:  161     ISSN:  0165-5728     ISO Abbreviation:  J. Neuroimmunol.     Publication Date:  2005 Apr 
Date Detail:
Created Date:  2005-03-07     Completed Date:  2005-05-27     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  8109498     Medline TA:  J Neuroimmunol     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  137-44     Citation Subset:  IM    
Affiliation:
Center for Perinatal Biology Research, Department of Physiology, School of Medicine, Loma Linda University Adventist Health Sciences Center, Loma Linda, CA, USA. syellon@som.llu.edu
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MeSH Terms
Descriptor/Qualifier:
Analysis of Variance
Animals
Cricetinae
Cytotoxicity Tests, Immunologic / methods
Fluoresceins / metabolism
Killer Cells, Natural / immunology,  radiation effects*
Light
Male
Organ Size / physiology,  radiation effects
Phagocytes / immunology,  radiation effects*
Phodopus
Photoperiod*
Pineal Gland / cytology,  immunology*
Testis / physiology,  radiation effects
Time Factors
Grant Support
ID/Acronym/Agency:
R01 NS40254/NS/NINDS NIH HHS
Chemical
Reg. No./Substance:
0/Fluoresceins; 2044-85-1/diacetyldichlorofluorescein

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