Document Detail

Time course of recovery of juvenile skeletal muscle after botulinum toxin A injection: an animal model study.
MedLine Citation:
PMID:  15385786     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To study the effects of neuromuscular blockade using botulinum toxin A on juvenile muscles at a dosage of 6 units/kg body weight in a rat model. DESIGN: A total of 34 male Sprague-Dawley rats (1-mo old) were used. A small incision was made along the posterior aspect of the left hind leg with the exposure of the gastrocnemius. Botulinum toxin A was injected at a dosage of 6 units/kg body weight in the medial and lateral heads of the muscle. An equivalent volume of saline were injected into the right gastrocnemius (control). Motor evoked action potentials, muscle force generation, and muscle mass and neuromuscular junction morphometry were analyzed at different time intervals up to 1 yr after toxin injection. RESULTS: During the 1-2 wks after botulinum toxin A injection, muscle mass, electrophysiologic variables, and muscle force generation were significantly reduced but returned to nearly normal at 6 mos postinjection. In the study group, neuromuscular junction gutter depth became significantly shallower 2 mos after injection, then normalized at 1 yr. There was a nonsignificant trend toward larger neuromuscular junctions from the gastrocnemius injected with botulinum toxin A. CONCLUSION: Our findings provide scientific evidence to support the clinical situation in which the interinjection interval of 3-6 mos of botulinum toxin A at a similar dosage is used.
Jianjun Ma; Gamal A Elsaidi; Thomas L Smith; Francis O Walker; Kim H Tan; Eileen Martin; L Andrew Koman; Beth Paterson Smith
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  American journal of physical medicine & rehabilitation / Association of Academic Physiatrists     Volume:  83     ISSN:  0894-9115     ISO Abbreviation:  Am J Phys Med Rehabil     Publication Date:  2004 Oct 
Date Detail:
Created Date:  2004-09-23     Completed Date:  2004-10-15     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8803677     Medline TA:  Am J Phys Med Rehabil     Country:  United States    
Other Details:
Languages:  eng     Pagination:  774-80; quiz 781-3     Citation Subset:  AIM; IM    
Department of Orthopaedic Surgery, Wake Forest University Health Sciences, Winston-Salem, North Carolina 27157, USA.
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MeSH Terms
Body Weights and Measures
Botulinum Toxin Type A / administration & dosage*
Disease Models, Animal
Injections, Intramuscular
Muscle, Skeletal / drug effects*,  physiology*
Rats, Sprague-Dawley
Recovery of Function
Time Factors
Reg. No./Substance:
0/Botulinum Toxin Type A

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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