Document Detail

Time course of the recovery of adenosine triphosphate content with adenosine in post-ischemic hearts--a 31P magnetic resonance spectroscopy study.
MedLine Citation:
PMID:  7967008     Owner:  NLM     Status:  MEDLINE    
Restoration of the ATP level after brief ischemia is limited by slow de novo ATP synthesis and substrate loss in a salvage pathways for ATP synthesis, and complete recovery requires several days in the stunned heart. Adenosine is a substrate for myocardial ATP synthesis. We measured myocardial ATP in both ex vivo and in vivo experiments by 31P magnetic resonance spectroscopy (31P-MRS) and investigated the time course of ATP content recovery after application of adenosine. Guinea-pig perfused hearts were subjected to 30 min of global ischemia and reperfused for 3 h with 50 microM adenosine. The ATP level increased from 54 +/- 5% to 117 +/- 4% of the pre-ischemic value (p < 0.01). In dogs, we occluded the left anterior descending coronary artery for 40 min to produce regional ischemia. Afterwards, we administered 100 mumol/h adenosine into the left ventricle for 2 h. ATP levels increased from 63 +/- 4% to 77 +/- 5% of the pre-ischemic value with adenosine (p < 0.05). However, ATP levels did not increase for a few hours after reperfusion both ex vivo and in vivo. Our 31P-MRS studies demonstrated that brief ischemia depressed ATP levels and that administration of adenosine accelerated ATP formation in post-ischemic hearts.
M Yoshiyama; M Ishikawa; I Miura; K Takeuchi; T Takeda
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Publication Detail:
Type:  In Vitro; Journal Article    
Journal Detail:
Title:  Japanese circulation journal     Volume:  58     ISSN:  0047-1828     ISO Abbreviation:  Jpn. Circ. J.     Publication Date:  1994 Aug 
Date Detail:
Created Date:  1994-12-23     Completed Date:  1994-12-23     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7806868     Medline TA:  Jpn Circ J     Country:  JAPAN    
Other Details:
Languages:  eng     Pagination:  662-70     Citation Subset:  IM    
First Department of Internal Medicine Osaka City University Medical School, Japan.
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MeSH Terms
Adenosine / metabolism*
Adenosine Triphosphate / biosynthesis*
Guinea Pigs
Magnetic Resonance Spectroscopy
Myocardial Ischemia / metabolism*
Myocardium / metabolism
Reg. No./Substance:
56-65-5/Adenosine Triphosphate; 58-61-7/Adenosine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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