| Time course of proadrenomedullin in the early phase of septic shock. A comparative study with other proinflammatory proteins. | |
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MedLine Citation:
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PMID: 22801438 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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AIM: It has been shown that pro-adrenomedullin is a good marker of the severity of septic shock but there are no data on the early changes in serum pro-adrenomedullin concentrations in patients with shock. METHODS: Twenty-one patients with septic shock and 21 healthy subjects studied as controls. Serum concentrations of pro-adrenomedullin, procalcitonin, ferritin, CRP and IL-6 were determined in all subjects at the initial observation. Patients with septic shock were also studied after 24 and 48 hours. RESULTS: The concentrations of the acute phase proteins were significantly higher in patients with septic shock than in the control subjects during the entire study period (P<0.001). Only procalcitonin significantly decreased on the third day of observation with respect to both the first day (P=0.002) and the second day (P=0.006). Proadrenomedullin (P=0.017) and IL-6 (P=0.001) showed an AUC significantly different from the null hypothesis in differentiating the patients who survived and those who did not. The sensitivity and specificity of pro-adrenomedullin in the assessment of death were 71.4% and 72.7%, respectively, while IL-6 had a sensitivity of 92.9% and a specificity of 60.6%. CONCLUSION: Proadrenomedullin is a reliable prognostic marker in patients with shock; further studies on a more consistent number of septic patients will definitively assess whether proadrenomedullin may replace the current prognostic markers in critically ill patients with shock due to sepsis. |
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Authors:
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R Pezzilli; A Barassi; A Pigna; A M Morselli-Labate; A Imbrogno; D Fabbri; G Di Nino; R Corinaldesi; G Melzi D'Eril |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Panminerva medica Volume: 54 ISSN: 1827-1898 ISO Abbreviation: Panminerva Med Publication Date: 2012 Sep |
Date Detail:
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Created Date: 2012-07-17 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0421110 Medline TA: Panminerva Med Country: Italy |
Other Details:
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Languages: eng Pagination: 211-7 Citation Subset: IM |
Affiliation:
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Department of Digestive Diseases and Internal Medicine, Sant'Orsola-Malpighi Hospital, Alma Mater Studiorum University of Bologna, Bologna - raffaele.pezzilli@aosp.bo.it. |
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