Document Detail

Time course of peripheral oxidative stress as consequence of global ischaemic brain injury in rats.
MedLine Citation:
PMID:  18058017     Owner:  NLM     Status:  MEDLINE    
Free radicals play an important role in the pathogenesis of brain injury. This study evaluates the potential relationship between ischaemia/reperfusion (I/R)-induced brain injury, peripheral oxidative stress (lymphocyte DNA damage), plasma antioxidant potential and uric acid levels. We observed that 15 min of ischaemia were sufficient to significantly increase lymphocyte DNA damage that remained elevated at the end of early (3 h) reperfusion and at later (72 h) reperfusion time; this parameter was not significantly increased, when compared to preoperated levels. In parallel, antioxidant potential was elevated after 15 min of ischaemia, remained high at early (3 h) reperfusion and decreased again with longer (72 h) reperfusion. A close association between the plasma antioxidant status and the uric acid content has been confirmed by findings that changes in TRAP values positively correlate with uric acid concentration in rat plasma after ischaemic injury. Moreover, results of in vitro experiments with extra uric acid addition to control plasma have shown that uric acid contributes to a greater part of TRAP values. These results indicate a similar time course of brain I/R-associated oxidative stress and peripheral antioxidant defence status and/or oxidative stress in animal experiments.
Monika Sivonová; Peter Kaplán; Zdenka Duracková; Dusan Dobrota; Anna Drgová; Zuzana Tatarková; Martina Pavlíková; Erika Halasová; Jan Lehotský
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2007-12-04
Journal Detail:
Title:  Cellular and molecular neurobiology     Volume:  28     ISSN:  0272-4340     ISO Abbreviation:  Cell. Mol. Neurobiol.     Publication Date:  2008 May 
Date Detail:
Created Date:  2008-03-04     Completed Date:  2008-08-11     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8200709     Medline TA:  Cell Mol Neurobiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  431-41     Citation Subset:  IM    
Jessenius Faculty of Medicine, Department of Medical Biochemistry, Comenius University, Malá hora 4, 036 01, Martin, Slovakia.
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MeSH Terms
Antioxidants / metabolism
Brain Injuries / complications*,  pathology
DNA Damage* / physiology
Free Radicals / blood,  metabolism
Lymphocytes / metabolism*,  pathology*
Oxidative Stress / physiology*
Rats, Wistar
Reperfusion Injury / complications*,  pathology
Time Factors
Uric Acid / blood
Reg. No./Substance:
0/Antioxidants; 0/Free Radicals; 69-93-2/Uric Acid

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