| Time course of motor behavior changes in Mongolian gerbils submitted to different durations of cerebral ischemia. | |
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MedLine Citation:
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PMID: 17067689 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In addition to morphological changes, global cerebral ischemia leads to functional changes that can be assessed by behavioral examination. The purpose of this study was to investigate the impact of the duration of global cerebral ischemia on the time course of a comprehensive set of motor behaviors in Mongolian gerbils. The common carotid arteries of gerbils were occluded either for 5 min, 10 min, or 15 min. Gerbil motor behavior was recorded in the open field at 24 h, 48 h, 4 days, 7 days, 14 days, 21 days, and 28 days after reperfusion. Each session lasted for 60 min and was composed of six intervals of 10 min. Our results revealed that ischemic gerbils quickly develop locomotor and stereotypic hyperactivity, with the expected decrease of resting time. The most evident effect was observed in gerbils submitted to a 15 min ischemia, whose locomotor activity returned to nearly normal values after 7 days. In contrast, the duration of global cerebral ischemia had no effects on rearing, clockwise, or counter-clockwise rotation. These findings indicate that exposure to global cerebral ischemia induces changes in locomotion, stereotypy, and resting time. The magnitude and duration of these effects depend on the duration of ischemia. |
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Authors:
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Branka Janać; Lidija Radenović; Vesna Selaković; Zlatko Prolić |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't; Validation Studies Date: 2006-10-25 |
Journal Detail:
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Title: Behavioural brain research Volume: 175 ISSN: 0166-4328 ISO Abbreviation: Behav. Brain Res. Publication Date: 2006 Dec |
Date Detail:
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Created Date: 2006-11-20 Completed Date: 2007-01-11 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8004872 Medline TA: Behav Brain Res Country: Netherlands |
Other Details:
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Languages: eng Pagination: 362-73 Citation Subset: IM |
Affiliation:
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Institute for Biological Research, Belgrade, Serbia. janac@ibiss.bg.ac.yu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Analysis of Variance Animals Brain Ischemia / complications*, physiopathology Disease Models, Animal Exploratory Behavior / physiology* Gerbillinae Hyperkinesis / etiology*, physiopathology Male Motor Activity / physiology* Recovery of Function / physiology Stereotyped Behavior / physiology* Time Factors |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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