Document Detail

Time course of lysophosphatidylcholine release from ischemic human myocardium parallels the time course of early ischemic ventricular arrhythmia.
MedLine Citation:
PMID:  9101118     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: We determined the kinetics of the release of lysophosphatidylcholine (LPC) into the coronary sinus of patients undergoing stress tests after coronary artery bypass grafting. The kinetics were consistent with a role for this amphiphile in the pathogenesis of ischemic ventricular arrhythmia, a major cause of sudden death. METHODS: Stress testing was initiated in the operating suite by pacing at a rate of 160 beats/min for 2 min. Ischemia was then induced by clamping the bypass grafts to the anterior wall for a maximal time of 4 min. RESULTS: The pacing procedure induced a prompt but reversible increase in coronary sinus LPC concentration from a baseline of 60.9 +/- 2.5 to 83.8 +/- 5.0 mumol/l via pacing alone, and a further increase to 101.8 +/- 6.7 mumol/l when the grafts were clamped for 2 min (P < 0.01). Six minutes after the cessation of pacing, LPC concentration returned to 67.5 +/- 4.4 mumol/l. CONCLUSIONS: These results demonstrate that severe myocardial ischemia is an agonist for rapid release of LPC from the myocardium. Kinetics of this release paralleled the time-course of early onset of electrophysiologic changes in isolated myocytes and perfused heart preparations in vitro. These results indicate that LPC may have an important role in the pathogenesis of ischemic ventricular arrhythmia in patients.
S P Sedlis; M Hom; J M Sequeira; M Tritel; A Gindea; J H Ladenson; A S Jaffe; R Esposito
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Coronary artery disease     Volume:  8     ISSN:  0954-6928     ISO Abbreviation:  Coron. Artery Dis.     Publication Date:  1997 Jan 
Date Detail:
Created Date:  1997-06-23     Completed Date:  1997-06-23     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  9011445     Medline TA:  Coron Artery Dis     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  19-27     Citation Subset:  IM    
Division of Cardiology, New York Department of Veterans Affairs Medical Center, New York, USA.
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MeSH Terms
Arrhythmias, Cardiac / etiology*,  physiopathology
Cardiac Pacing, Artificial
Coronary Artery Bypass
Coronary Disease / surgery
Lysophosphatidylcholines / blood,  metabolism*
Myocardial Ischemia / complications*,  metabolism,  physiopathology
Myocardium / metabolism*
Time Factors
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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