Document Detail


Time course of intracranial hypertension after traumatic brain injury.
MedLine Citation:
PMID:  17711395     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
High intracranial pressure (HICP) may be a very early event after traumatic brain injury (TBI), but in most cases, especially when contusions and edema develop over time, HICP will worsen over succeeding days. This study describes the incidence and severity of elevated intracranial pressure (ICP) after TBI and attempts to document its time course. In this prospective study, 201 TBI patients in whom ICP was monitored for more than 12 h were evaluated. ICP was measured, digitalized, and analyzed after manual filtering. The number of episodes of HICP and the mean ICP value for every 12-h interval were calculated. When monitoring was concluded, the highest mean ICP collected in every patient was identified. A total of 21,000 h of ICP monitoring were recorded. Active treatment to prevent or reduce HICP was used in 200 patients. HICP was documented in 155 cases. Half of the patients had their highest mean ICP during the first 3 days after injury, but many showed delayed ICP elevation, with 25% showing highest mean ICP after day 5. In these cases, HICP was significantly worse and required more intense therapies.
Authors:
Nino Stocchetti; Angelo Colombo; Fabrizio Ortolano; Walter Videtta; Roberta Marchesi; Luca Longhi; Elisa R Zanier
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of neurotrauma     Volume:  24     ISSN:  0897-7151     ISO Abbreviation:  J. Neurotrauma     Publication Date:  2007 Aug 
Date Detail:
Created Date:  2007-08-22     Completed Date:  2007-12-18     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8811626     Medline TA:  J Neurotrauma     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1339-46     Citation Subset:  IM    
Affiliation:
Anesthesia and Intensive Care Medicine, Milan University, Neuroscience ICU, Fondazione IRCCS Ospedale Maggiore Policlinico, Mangiagalli, e Regina Elena, Milan, Italy. stocchet@policlinico.mi.it
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MeSH Terms
Descriptor/Qualifier:
Adult
Brain Injuries / physiopathology*,  radiography,  therapy
Female
Follow-Up Studies
Glasgow Coma Scale
Glasgow Outcome Scale
Humans
Incidence
Intracranial Hypertension / epidemiology*,  radiography,  therapy
Male
Middle Aged
Prospective Studies
Time Factors
Treatment Outcome

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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