Document Detail


Time course and inhibition of saponin-induced hemolysis.
MedLine Citation:
PMID:  1529023     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Hemolytic activities of 3 steroid saponins reached plateaus within 5 min, whereas those of 4 triterpenoid saponins did not within 60 min. Erythrocytes pretreated with a low concentration of tigogenin were resistant to hemolysis of some of these saponins, but those pretreated with hecogenin or tomatidine were as sensitive as non-treated erythrocytes. Therefore, the ketone group of hecogenin or the amino group of tomatidine would weaken the interactions between the erythrocytes and these sapogenins. Furthermore, incubations of these saponins with a small amount of cholesterol diminished the hemolytic activities.
Authors:
M Takechi; S Shimada; Y Tanaka
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Publication Detail:
Type:  In Vitro; Journal Article    
Journal Detail:
Title:  Planta medica     Volume:  58     ISSN:  0032-0943     ISO Abbreviation:  Planta Med.     Publication Date:  1992 Apr 
Date Detail:
Created Date:  1992-10-22     Completed Date:  1992-10-22     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0066751     Medline TA:  Planta Med     Country:  GERMANY    
Other Details:
Languages:  eng     Pagination:  128-30     Citation Subset:  IM    
Affiliation:
Faculty of Pharmaceutical Sciences, Kinki University, Higashiosaka, Japan.
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MeSH Terms
Descriptor/Qualifier:
Animals
Erythrocytes / drug effects
Hemolysin Proteins*
Lipids / pharmacology
Sapogenins / pharmacology
Saponins / antagonists & inhibitors,  pharmacology*
Sheep
Time Factors
Chemical
Reg. No./Substance:
0/Hemolysin Proteins; 0/Lipids; 0/Sapogenins; 0/Saponins

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