Document Detail

Time course of endocrine changes in the hypophysis-gonad axis induced by hypobaric hypoxia in male rats.
MedLine Citation:
PMID:  17984574     Owner:  NLM     Status:  MEDLINE    
Chronic hypobaric hypoxia (CHH) induces a decrease in sperm output and spermatogenesis in male rats. The mechanisms that underlie these changes in testicular function are unknown and could involve changes in the hypophysis-gonad axis. We have tested the hypothesis that changes take place in the endocrine status (FSH, follicle stimulating hormone; LH, luteinizing hormone; testosterone) of rats subjected to CHH. Male Wistar rats were maintained under normobaric or hypobaric conditions (428 torr, 4,600 m). On days 0, 5, 15 and 30 post-exposure, 12 rats were anesthetized, their body weights were measured and blood samples were collected. The testicles were fixed in 4% formaldehyde and processed for histological analysis. In this time course, the FSH levels rose by day 5 post-exposure. On subsequent days, the FSH levels decreased in rats subjected to CHH with a tendency to remain higher than the normoxic group. The LH plasma levels decreased in rats exposed to CHH. Consistent with the decrease in LH levels, the plasma testosterone level decreased significantly after 30 days of CHH exposure. Integrated analysis of hormonal changes in rats subjected to CHH and the body dehydration that occurs in HH allows us to conclude that the effects of CHH on spermatogenesis may be partially related to changes in the hypophysis-gonad hormonal axis.
Jorge Gonzalo Farias; Eduardo Bustos-Obregón; Pablo Jose Tapia; Eduardo Gutierrez; Andrea Zepeda; Camila Juantok; Gonzalo Cruz; Gustavo Soto; Julio Benites; Juan Guillermo Reyes
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2007-11-02
Journal Detail:
Title:  The Journal of reproduction and development     Volume:  54     ISSN:  0916-8818     ISO Abbreviation:  J. Reprod. Dev.     Publication Date:  2008 Feb 
Date Detail:
Created Date:  2008-03-05     Completed Date:  2008-05-06     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9438792     Medline TA:  J Reprod Dev     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  18-21     Citation Subset:  IM    
Universidad Arturo Prat-Centro de Investigaciones del Hombre del Desierto, Iquique, Chile.
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MeSH Terms
Anoxia / blood*,  physiopathology
Dehydration / physiopathology
Eating / physiology*
Follicle Stimulating Hormone / blood*
Infertility, Male / physiopathology
Luteinizing Hormone / blood*
Pituitary Gland / secretion
Rats, Wistar
Spermatogenesis / physiology
Testis / secretion
Testosterone / blood*
Reg. No./Substance:
58-22-0/Testosterone; 9002-67-9/Luteinizing Hormone; 9002-68-0/Follicle Stimulating Hormone

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