Document Detail

Time course of discordant BMIPP and thallium uptake after ischemia and reperfusion in a rat model.
MedLine Citation:
PMID:  15632049     Owner:  NLM     Status:  MEDLINE    
Serial changes in fatty acid metabolism or use associated with acute ischemia and reperfusion were examined in rat hearts. METHODS: Male Wistar rats were subjected to occlusion of the left coronary artery for 20 min followed by reperfusion. After release of the occlusion, groups of animals were allowed to recover for intervals of 20 min (n = 9), 1 d (n = 9), 3 d (n = 6), 7 d (n = 6), or 30 d (n = 6). Hearts were excised 15-20 min after injection of 0.74 MBq of (125)I-15-(p-iodophenyl)-3-R,S-methylpentadecanoic acid (BMIPP) and 14.8 MBq of (201)Tl. One minute before resection, the left coronary artery was reoccluded and 185 MBq of (99m)Tc-sestamibi were injected to document the area at risk. Triple-tracer autoradiography was performed to assess tracer uptake. Uptake ratios of BMIPP and (201)Tl in the area at risk were calculated on the basis of the count density in the lesion divided by that in the normally perfused area. RESULTS: (201)Tl uptake did not change throughout the observation period (P = 0.25). In contrast, BMIPP uptake increased early in the acute phase (20 min and 1 d), decreased during the subacute phase (7 d), and subsequently recovered in the chronic phase (30 d). CONCLUSION: The present investigation clearly illustrated that BMIPP uptake is higher than (201)Tl uptake in the acute phase, that BMIPP uptake is lower than (201)Tl uptake in the subacute phase, and that BMIPP uptake and (201)Tl uptake are similar in the chronic phase. These results yield data essential to the precise interpretation of BMIPP images.
Takahiro Higuchi; Junichi Taki; Kenichi Nakajima; Seigo Kinuya; Masanobu Namura; Norihisa Tonami
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Publication Detail:
Type:  Comparative Study; Evaluation Studies; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of nuclear medicine : official publication, Society of Nuclear Medicine     Volume:  46     ISSN:  0161-5505     ISO Abbreviation:  J. Nucl. Med.     Publication Date:  2005 Jan 
Date Detail:
Created Date:  2005-01-05     Completed Date:  2005-03-29     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0217410     Medline TA:  J Nucl Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  172-5     Citation Subset:  IM    
PET Center, Kanazawa Cardiovascular Hospital, Kanazawa, Japan.
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MeSH Terms
Disease Models, Animal
Fatty Acids / diagnostic use*,  pharmacokinetics*
Heart / radionuclide imaging*
Iodine Radioisotopes / diagnostic use,  pharmacokinetics
Iodobenzenes / diagnostic use*,  pharmacokinetics*
Metabolic Clearance Rate
Myocardium / metabolism*
Radiopharmaceuticals / diagnostic use,  pharmacokinetics
Rats, Wistar
Reperfusion Injury / metabolism*,  radionuclide imaging*
Thallium / diagnostic use*,  pharmacokinetics*
Tissue Distribution
Reg. No./Substance:
0/Fatty Acids; 0/Iodine Radioisotopes; 0/Iodobenzenes; 0/Radiopharmaceuticals; 116754-87-1/iodofiltic acid; 7440-28-0/Thallium; 7791-12-0/thallium chloride

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