| Time course of classically conditioned purkinje cell response is determined by initial part of conditioned stimulus. | |
| | |
MedLine Citation:
|
PMID: 21697357 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
|
Classical conditioning of a motor response such as eyeblink is associated with the development of a pause in cerebellar Purkinje cell firing that is an important driver of the overt response. This conditioned Purkinje cell response is adaptively timed and has a specific temporal profile that probably explains the time course of the overt behavior. It is generally assumed that the temporal properties of the conditioned Purkinje cell response are determined by the temporal pattern of the parallel fiber impulses generated by the conditioned stimulus at the time of the conditioned response. We show here in the decerebrate ferret preparation that a very brief conditioned stimulus, consisting of only one or two impulses in the mossy fibers, can be sufficient to elicit a full conditioned Purkinje cell response with normal time course. The finding suggests that parallel fiber input to the Purkinje cell influences the firing rate several hundred milliseconds later. It poses a serious challenge to the standard view of the role of parallel fiber impulses in response timing. |
| | |
Authors:
|
Dan-Anders Jirenhed; Germund Hesslow |
Related Documents
:
|
17532637 - The biomechanics of step descent under different treatment modalities used in patellofe... 7729837 - The dynamic response of the cat ankle joint during load-moving contractions. 2292647 - Continuous passive motion following partial ankle joint arthroplasty. 14582527 - Assessment of an electronic goniometer designed to measure equinus contracture. 7358907 - Systematic errors in indirect estimates of basilar membrane travel times. 20170947 - Initial dynamic viscoelasticity change of composites during light curing. |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: The Journal of neuroscience : the official journal of the Society for Neuroscience Volume: 31 ISSN: 1529-2401 ISO Abbreviation: J. Neurosci. Publication Date: 2011 Jun |
Date Detail:
|
Created Date: 2011-06-23 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 8102140 Medline TA: J Neurosci Country: United States |
Other Details:
|
Languages: eng Pagination: 9070-4 Citation Subset: IM |
Affiliation:
|
Department of Experimental Medical Science, Lund University, 22184 Lund, Sweden. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Ticagrelor Inhibits Adenosine Uptake In Vitro and Enhances Adenosine-Mediated Hyperemia Responses in...
Next Document: Constant darkness induces IL-6-dependent depression-like behavior through the NF-?B signaling pathwa...