| Time course characteristics of acute tolerance development to continuously infused alfentanil in rats. | |
| | |
MedLine Citation:
|
PMID: 8780289 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
The time course of the development of acute tolerance to alfentanil was characterized in rat experiments using various algorithms of continuous infusion of the drug. To maintain analgesia at a constant level (tail compression test), alfentanil use was steadily increased: Time to 50% increase in alfentanil use was 255 +/- 98 min with analgesia maintained at a level of 50% increase in the pressure threshold, and 203 +/- 116 min with analgesia maintained at a level of 200% increase. With the use of the alfentanil infusion regimen designed to rapidly achieve and maintain the constant alfentanil plasma concentration (120 ng/mL), the rate of development of acute tolerance, measured in terms of time to 50% recovery during continuing infusion, was 81 +/- 26 min with the compression test and 88 +/- 38 min with the hot-plate test, but 374 +/- 46 min with the rotarod test (P < 0.0001). Thus we demonstrated rapid development of acute tolerance to continuously infused alfentanil with different methods of tolerance assessment. The results also indicate that the time course of tolerance development does not depend on the type of noxious stimulation (mechanical versus thermal) if the response is organized predominantly supraspinally, and that acute tolerance to the direct effect of alfentanil on motor functions does not mask the rapid development of tolerance to its analgesic effect. |
| | |
Authors:
|
I Kissin; S S Lee; G R Arthur; E L Bradley |
Related Documents
:
|
11437759 - Redistribution of halothane and sevoflurane under simulated conditions of acute airway ... 8053589 - Neuromuscular effects of rocuronium bromide and mivacurium chloride administered alone ... 16874309 - Bioequivalence of topical formulations in humans: evaluation by dermal microdialysis sa... 22267569 - Cough and upper airway disorders in elite athletes: a critical review. 11573589 - Infusion of amino acid enriched solution hastens recovery from neuromuscular block caus... 23600729 - The effects of physical activity and exercise on brain-derived neurotrophic factor in h... 17676679 - Exercise behaviours and feelings in eating disorder and non-eating disorder groups. 11745129 - Effects of furfural on anaerobic continuous cultivation of saccharomyces cerevisiae. 17961919 - Influence of physical training on the syrian hamster's melatonin rhythm. |
Publication Detail:
|
Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
|
Title: Anesthesia and analgesia Volume: 83 ISSN: 0003-2999 ISO Abbreviation: Anesth. Analg. Publication Date: 1996 Sep |
Date Detail:
|
Created Date: 1996-10-09 Completed Date: 1996-10-09 Revised Date: 2008-11-21 |
Medline Journal Info:
|
Nlm Unique ID: 1310650 Medline TA: Anesth Analg Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: 600-5 Citation Subset: AIM; IM |
Affiliation:
|
Department of Anesthesia, Harvard Medical School, Brigham and Women's Hospital, Boston, Massachusetts 02115, USA. kissin@zeus.bwh.harvard.edu |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Alfentanil
/
administration & dosage*,
pharmacology Analgesics, Opioid / administration & dosage*, pharmacology Animals Drug Tolerance Hot Temperature Infusions, Intravenous Male Pain Threshold Pressure Rats Rats, Sprague-Dawley Sensory Thresholds Time Factors |
| Grant Support | |
ID/Acronym/Agency:
|
GM-35135/GM/NIGMS NIH HHS |
| Chemical | |
Reg. No./Substance:
|
0/Analgesics, Opioid; 71195-58-9/Alfentanil |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Enflurane decreases the threshold for vasoconstriction more than isoflurane or halothane.
Next Document: Hypnotic and analgesic effects of the alpha 2-adrenergic agonist dexmedetomidine in morphine-toleran...