| [Time-course changes of myogenic tone of mesenteric small artery in spontaneously hypertensive rat]. | |
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MedLine Citation:
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PMID: 22348962 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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To investigate the time-course changes of myogenic tone in mesenteric small artery (MSA) of spontaneously hypertensive rat (SHR), thirty-two 7-week aged SHR rats were randomly divided into four groups (8, 16, 24, 32 weeks of age), and 32 sex- and age-matched Wistar-Kyoto (WKY) rats were assigned to control groups (CON). On the day of the study, segments of MSA were isolated and then cannulated to the two pipettes. Vascular diameters in response to the increased intraluminal pressure (from 0 mmHg to 150 mmHg, by 25 mmHg steps) of isolated MSA under no-flow conditions were recorded by a Pressure Myograph System both in physiologic salt solution (PSS) (active diameter, Da) and calcium-free PSS (passive diameter, Dp). The myogenic tone was calculated by (Dp - Da)/Dp × 100%. The tail artery pressure and vascular myogenic tone in SHR rats were significantly higher than those of the CON rats. Before 24 weeks, the vascular myogenic tone of MSA in SHR group increased monotonically, but at the end of 32 weeks, the vascular myogenic tone decreased in comparison with that in 24-week group, but was significantly higher than that in CON group. The tail artery pressure in SHR group slowly increased monotonically with increasing weeks of age, and the tail arterial pressure in 32-week group remained significantly higher than that in 24-week group. Vascular myogenic tone may participate in the whole process of hypertension. Early in the development of hypertension, because of the compensatory role of vascular tone, the vascular function has been partially compensated, thus guaranteeing adequate blood supply to organs. Late in the development of hypertension, because of the decompensation of myogenic tone, the vascular function is damaged, leading to the occurrence of severe vascular disease. |
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Authors:
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Le-Jian Lin; Fa-Kuan Tang; Ning Hua; Hong Lu; Chun-Xia DI; Xue-Zheng Tang; Yu Li |
Publication Detail:
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Type: English Abstract; Journal Article |
Journal Detail:
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Title: Sheng li xue bao : [Acta physiologica Sinica] Volume: 64 ISSN: 0371-0874 ISO Abbreviation: Sheng Li Xue Bao Publication Date: 2012 Feb |
Date Detail:
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Created Date: 2012-02-21 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 20730130R Medline TA: Sheng Li Xue Bao Country: China |
Other Details:
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Languages: chi Pagination: 62-8 Citation Subset: IM |
Affiliation:
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Department of Cardiology, 309 Hospital of the Chinese People's Liberation Army, Beijing 100091, China. E-mail: lejianlin118@gmail.com. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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