Document Detail

Time course of changes in nail fold microcirculation induced by acupuncture stimulation at the Waiguan acupoints.
MedLine Citation:
PMID:  17080544     Owner:  NLM     Status:  MEDLINE    
Acupuncture has been used widely to treat disease; however, the time course for acupuncture to have an effect remains unclear. Therefore, the aim of the present study was to investigate the time course of changes in nail fold microcirculation (NFM) induced by acupuncture stimulation (AS) at the right and left Waiguan acupoints (WAs). A total of 38 healthy female volunteers, age range from 21 to 33, were studied. We recorded NFM of the right middle finger before, and 5 min, 10 min, 15 min and 20 min after initiating AS; NFM was also recorded 5 min and 10 min after secessions of AS. Nitric oxide (NO) and endothelin-1 levels were measured from the left cubital vein, before AS and 10 min after stopping AS. The results indicated that capillary density of NFM increased 5 min after AS at the right Waiguan acupoint (WA); however, similar changes were not noted at the left WA. The capillary density decreased beginning 15 min after AS at the right and left WA. Capillary red blood cell velocity increased 5 min and 10 min after AS at the right and left WAs, but decreased 5 min and 10 min after stopping AS at the left WA. NO and endothein-1 levels were similar before AS and 10 min after stopping AS. Therefore, we suggest that a segmental effect of the spinal nerve contributes to the increasing capillary density of NFM induced by AS. The effect of acupuncture on NFM lasts about 10-15 min. The changes of balance between the sympathetic nerve activities and parasympathetic nerve activities may be induced by AS.
Ching-Liang Hsieh; Yung-Ming Chang; Nou-Ying Tang; I-hsin Lin; Chung-Hsiang Liu; Jaung-Geng Lin; Rui Jin
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Publication Detail:
Type:  Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The American journal of Chinese medicine     Volume:  34     ISSN:  0192-415X     ISO Abbreviation:  Am. J. Chin. Med.     Publication Date:  2006  
Date Detail:
Created Date:  2006-11-02     Completed Date:  2010-03-12     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7901431     Medline TA:  Am J Chin Med     Country:  Singapore    
Other Details:
Languages:  eng     Pagination:  777-85     Citation Subset:  IM    
Department of Chinese Medicine, China Medical University, Taichung, Taiwan, ROC.
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MeSH Terms
Acupuncture / methods*
Acupuncture Points*
Capillaries / physiology
Nails / blood supply*
Nitric Oxide / metabolism
Time Factors
Young Adult
Reg. No./Substance:
10102-43-9/Nitric Oxide

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