| Time course of changes in the concentrations of amino acids in the brain structures of pentylenetetrazole-kindled rats. | |
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MedLine Citation:
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PMID: 20420810 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The results showed that the development of seizures (pentylenetetrazole, PTZ-induced kindling; PTZ was administered to rats at a subconvulsive dose of 35mg/kg three times a week, i.p.) was accompanied by a progressive recruitment of limbic structures and a characteristic pattern of changes in the brain tissue concentration of examined amino acids (ex vivo measurements, 1.5h after the last dose of PTZ). The earliest and homogenous increase in the excitatory (glutamate and alanine) and inhibitory (GABA and taurine) amino acids was observed in the entorhinal cortex (at stages 1 and 2 according to Racine's scale), and this effect was maintained at the fifth stage of kindling (except for glutamate). At the fifth stage of kindling, glutamate was elevated in the amygdala, nucleus accumbens and piriform cortex, whereas alanine content was increased in the hippocampus, amygdala, striatum, nucleus accumbens and piriform cortex. In the case of GABA, a significant increase in the local concentration of this amino acid was found in rats with stage 1 and 2 seizures in the prefrontal and entorhinal cortices and a decrease was present in amygdala. Kindling raised the local level of taurine in the entorhinal cortex (stage 1 and 2 seizures), amygdala, nucleus accumbens and piriform cortex (stage 5 seizures). These data confirm the conclusion that separate seizure circuitries in the forebrain structures mutually interact to facilitate and/or inhibit one another. Overall, these data suggest that there is a shift in the balance between neurotransmitters toward increased production of excitatory amino acids. |
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Authors:
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Piotr Maciejak; Janusz Szyndler; Danuta Turzyńska; Alicja Sobolewska; Andrzej Bidziński; Karolina Kołosowska; Adam Płaźnik |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-04-24 |
Journal Detail:
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Title: Brain research Volume: 1342 ISSN: 1872-6240 ISO Abbreviation: Brain Res. Publication Date: 2010 Jun |
Date Detail:
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Created Date: 2010-06-14 Completed Date: 2011-01-18 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0045503 Medline TA: Brain Res Country: Netherlands |
Other Details:
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Languages: eng Pagination: 150-9 Citation Subset: IM |
Copyright Information:
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Copyright 2010 Elsevier B.V. All rights reserved. |
Affiliation:
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Department of Neurochemistry, Institute of Psychiatry and Neurology, 9 Sobieskiego Street, 02-957 Warsaw, Poland. piomac@yahoo.com |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Amino Acids
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metabolism* Animals Brain / drug effects, metabolism*, physiopathology Disease Models, Animal Epilepsy / metabolism* Kindling, Neurologic / metabolism* Male Neurotransmitter Agents / metabolism* Rats Rats, Wistar Time Factors |
| Chemical | |
Reg. No./Substance:
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0/Amino Acids; 0/Neurotransmitter Agents |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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