Document Detail

Time-course of the changes in blood pressure and in plasma renin activity during the first week after dilation of renal artery stenosis.
MedLine Citation:
PMID:  2534402     Owner:  NLM     Status:  MEDLINE    
We measured arterial pressure and plasma renin activity throughout the first week after a technically successful percutaneous transluminal renal angioplasty (PTRA) in 12 patients with hypertension and unilateral renal artery stenosis. Mean arterial pressure fell from 126 +/- 4 to 105 +/- 3 mmHg within 1-2 days of PTRA and stabilized thereafter; in addition, plasma renin activity decreased sharply during the first 2 days after the angioplasty (from 5.2 +/- 2.3 to 1.3 +/- 0.3 ng/ml per h) but continued to decline, reaching 0.8 +/- 0.2 ng/ml per h at the end of the study. When the antihypertensive effect of PTRA was examined in relation to baseline values of plasma renin activity, the patients with low, intermediate and high plasma renin activity showed percentage decreases in mean arterial pressure of, respectively, 6%, 16% and 19% by the sixth day of observation after the angioplasty. No overall correlation was found between the changes in arterial pressure and those in plasma renin activity induced by PTRA. These data suggest that the beneficial effect of PTRA on blood pressure can be estimated within a few days and that the reduction in the activity of the renin system is the principal but not the sole mechanism responsible for it.
A Morganti; P Quorso; P Ferraris; A Lovaria; M Fruscio; S Saccheri; A Zanchetti
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of hypertension. Supplement : official journal of the International Society of Hypertension     Volume:  7     ISSN:  0952-1178     ISO Abbreviation:  J Hypertens Suppl     Publication Date:  1989 Dec 
Date Detail:
Created Date:  1990-05-11     Completed Date:  1990-05-11     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  8501422     Medline TA:  J Hypertens Suppl     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  S186-7     Citation Subset:  IM    
Istituto di Clinica Medica Generale e Terapia Medica, Università di Milano, Italy.
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MeSH Terms
Angioplasty, Balloon*
Blood Pressure / physiology*
Evaluation Studies as Topic
Middle Aged
Renal Artery*
Renal Artery Obstruction / blood,  physiopathology*,  therapy
Renin / blood*
Time Factors
Reg. No./Substance:

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